Results 61 to 70 of about 3,540 (186)
Centriole duplication and maturation in animal cells
, 1999 Publisher Summary The functional role and structural features of the centriole and the molecular events underlying centriolar duplication and maturation are discussed in the chapter. The published data are reviewed, with emphasis on the centriole of mammalian cells.
Lange, B, Faragher, A, March, P, Gull, K
openaire +2 more sources
Polo-like kinase 4: the odd one out of the family
Cell Division, 2010 Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark +8 more
wiley +1 more source
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Nature Communications, 2019 Centriolar separation is thought to be crucial for centriole duplication, but the mechanism behind separation is poorly understood. Here, using micropatterning, the authors report that actomyosin forces influence the direction, distance, and time of ...
Elisa Vitiello +7 more
doaj +1 more source
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, EarlyView.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source
CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation
Cell Reports, 2019 Summary: In animal cells, centriole number is strictly controlled in order to guarantee faithful cell division and genetic stability, but the mechanism by which the accuracy of centrosome duplication is maintained is not fully understood.
Tianning Wang +4 more
doaj +1 more source
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation [PDF]
Open Biology, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Nikola S. Dzhindzhev +6 more
doaj +1 more source
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
eLife, 2015 Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homo-oligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved,
Matthew A Cottee +5 more
doaj +1 more source