Results 81 to 90 of about 273,445 (144)

Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

Biology Open, 2019
Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged
Daisuke Takao, Koki Watanabe, Kanako Kuroki, Daiju Kitagawa   +3 more
doaj   +1 more source

SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL

Journal of Cell Biology, 2019
Kodani et al. identify a role for the mammalian homologue of yeast SFI1 as a regulator of centriole duplication. They show that SFI1 localizes USP9X to the centrosome to stabilize the microcephaly protein STIL to promote centriole duplication.
Andrew Kodani, Tyler C. Moyer, Allen Y Chen, A. Holland, C. Walsh, Jeremy F. Reiter   +5 more
semanticscholar   +1 more source

Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication [PDF]

Current Biology, 2014
The centrosome consists of a pair of centrioles and surrounding pericentriolar material (PCM). Many vertebrate cells also have an array of granules, termed centriolar satellites, that localize around the centrosome and are associated with centrosome and cilium function.
Firat-Karalar, Elif Nur, Rauniyar, Navin, Yates, John R., Stearns, Tim   +3 more
openaire   +2 more sources

WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication

Journal of Cell Biology, 2019
Park et al. identify a role for a subset of mRNA splicing factors, including WBP11, in centriole biogenesis. WBP11 is required for the splicing of short, weak introns, including those found in TUBGCP6 pre-mRNA. Splicing of TUBGCP6, as well as other WBP11
Elizabeth Park, Phillip Scott, Kevin M. Clutario, Katelyn B. Cassidy, Kevin H. Zhan, S. Gerber, A. Holland   +6 more
semanticscholar   +1 more source

Cep57 and Cep57L1 cooperatively maintain centriole engagement during interphase to ensure proper centriole duplication cycle

bioRxiv, 2020
Centrioles duplicate in the interphase only once per cell cycle. Newly formed centrioles remain associated with their mother centrioles. The two centrioles disengage at the end of mitosis, which licenses centriole duplication in the next cell cycle ...
Kei Ito, Koki Watanabe, Haruki Ishida, Kyohei Matsuhashi, Takumi Chinen, S. Hata, Daiju Kitagawa   +6 more
semanticscholar   +1 more source

Cep152 interacts with Plk4 and is required for centriole duplication [PDF]

Journal of Cell Biology, 2010
Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M, Kulukian, Anita, Holland, Andrew J, Cleveland, Don W, Stearns, Tim   +4 more
openaire   +4 more sources

Drosophila Spd-2 Recruits PCM to the Sperm Centriole, but Is Dispensable for Centriole Duplication

Current Biology, 2007
In C. elegans, genome-wide screens have identified just five essential centriole-duplication factors: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4 [1-8]. These proteins are widely believed to comprise a conserved core duplication module [3, 9-14]. In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar
Dix, C, Raff, J
openaire   +3 more sources

The interrelationship between APC/C and Plk1 activities in centriole disengagement

Biology Open, 2012
Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation.
Toshiyuki Hatano, Greenfield Sluder
doaj   +1 more source

De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

eLife, 2015
Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the
Won-Jing Wang, Devrim Acehan, Chien-Han Kao, Wann-Neng Jane, Kunihiro Uryu, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source