Results 1 to 10 of about 7,664 (95)
C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]
Nature CommunicationsCentrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister +10 more
doaj +2 more sources
Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle [PDF]
Scientific ReportsCentrioles assemble and segregate in link to the cell cycle. Daughter centrioles assemble at S phase, and become young mother centrioles after M phase. Since distal appendages (DAs) are installed to young mother centrioles at the second G2/M transition ...
Dohyong Lee +6 more
doaj +2 more sources
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture [PDF]
eLifeCentrioles have a unique, conserved architecture formed by three linked, ‘triplet’, microtubules arranged in ninefold symmetry. The mechanisms by which these triplet microtubules are formed remain unclear but likely involve the noncanonical tubulins ...
Rachel Pudlowski +7 more
doaj +2 more sources
Meiotic divisions and round spermatid formation do not require centriole duplication in mice. [PDF]
PLoS GeneticsCentrosomes, composed of centrioles and pericentriolar matrix proteins, are traditionally viewed as essential microtubule-organizing centers (MTOCs) that facilitate bipolar spindle formation and chromosome segregation during spermatogenesis.
Marnie W Skinner +3 more
doaj +2 more sources
Long-range migration of centrioles to the apical surface of the olfactory epithelium
eLife, 2022 Olfactory sensory neurons (OSNs) in vertebrates detect odorants using multiple cilia, which protrude from the end of the dendrite and require centrioles for their formation. In mouse olfactory epithelium, the centrioles originate in progenitor cells near
Kaitlin Ching +2 more
doaj +1 more source
Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
doaj +1 more source
Cells, 2020 Drosophila spermatocytes have giant centrioles that display unique properties. Both the parent centrioles maintain a distinct cartwheel and nucleate a cilium-like region that persists during the meiotic divisions and organizes a structured sperm axoneme.
Veronica Persico +3 more
doaj +1 more source
Estrogens—Origin of Centrosome Defects in Human Cancer?
Cells, 2022 Estrogens are associated with a variety of diseases and play important roles in tumor development and progression. Centrosome defects are hallmarks of human cancers and contribute to ongoing chromosome missegragation and aneuploidy that manifest in ...
Miriam Bühler, Ailine Stolz
doaj +1 more source
Experimental and Natural Induction of de novo Centriole Formation
Frontiers in Cell and Developmental Biology, 2022 In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj +1 more source
Centrosome Formation in the Bovine Early Embryo
Cells, 2023 Centrosome formation during early development in mice and rats occurs due to the appearance of centrioles de novo. In contrast, in humans and other non-rodent mammals, centrioles are thought to be derived from spermatozoa.
Rustem Uzbekov +5 more
doaj +1 more source