Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles [PDF]
eLife, 2018 Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Garrett A Greenan +3 more
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C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]
Nature CommunicationsCentrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister +10 more
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Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle [PDF]
Scientific ReportsCentrioles assemble and segregate in link to the cell cycle. Daughter centrioles assemble at S phase, and become young mother centrioles after M phase. Since distal appendages (DAs) are installed to young mother centrioles at the second G2/M transition ...
Dohyong Lee +6 more
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Centrioles without microtubules: a new morphological type of centriole [PDF]
Biology Open, 2018 The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude.
Rustem Uzbekov +2 more
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A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture [PDF]
eLifeCentrioles have a unique, conserved architecture formed by three linked, ‘triplet’, microtubules arranged in ninefold symmetry. The mechanisms by which these triplet microtubules are formed remain unclear but likely involve the noncanonical tubulins ...
Rachel Pudlowski +7 more
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Meiotic divisions and round spermatid formation do not require centriole duplication in mice. [PDF]
PLoS GeneticsCentrosomes, composed of centrioles and pericentriolar matrix proteins, are traditionally viewed as essential microtubule-organizing centers (MTOCs) that facilitate bipolar spindle formation and chromosome segregation during spermatogenesis.
Marnie W Skinner +3 more
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NuSAP Safeguards Centriole Integrity to Mediate CEP57-CEP152 Torus Recruitment for Proper Engagement. [PDF]
Adv Sci (Weinh)This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Zhang S +8 more
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures.
Winey, Mark, O'Toole, Eileen
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Long-range migration of centrioles to the apical surface of the olfactory epithelium
eLife, 2022 Olfactory sensory neurons (OSNs) in vertebrates detect odorants using multiple cilia, which protrude from the end of the dendrite and require centrioles for their formation. In mouse olfactory epithelium, the centrioles originate in progenitor cells near
Kaitlin Ching +2 more
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Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
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