Results 21 to 30 of about 7,733 (159)
Prion, 2008 Early cell biologists perceived centrosomes to be permanent cellular structures. Centrosomes were observed to reproduce once each cycle and to orchestrate assembly a transient mitotic apparatus that segregated chromosomes and a centrosome to each daughter at the completion of cell division.
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The Centriole’s Role in Miscarriages
Frontiers in Cell and Developmental Biology, 2022 Centrioles are subcellular organelles essential for normal cell function and development; they form the cell’s centrosome (a major cytoplasmic microtubule organization center) and cilium (a sensory and motile hair-like cellular extension).
Tomer Avidor-Reiss +4 more
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Current Opinion in Cell Biology, 2009 Centrioles are cylindrical structures found at the core of the mitotic spindle pole, which also act as basal bodies to nucleate the formation of cilia. Centrioles have a complex, ninefold symmetric structure, and reproduce by an intriguing duplication process. The complexity and apparent self-reproduction of centrioles raises the question of how such a
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De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly
eLife, 2015 Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the
Won-Jing Wang +5 more
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Cells, 2020 Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially controlled ...
Catherine Sullenberger +3 more
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Stable centrosomal roots disentangle to allow interphase centriole independence.
PLoS Biology, 2018 The centrosome is a non-membrane-bound cellular compartment consisting of 2 centrioles surrounded by a protein coat termed the pericentriolar material (PCM).
Robert Mahen
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Flies without Centrioles [PDF]
Cell, 2006 Centrioles and centrosomes have an important role in animal cell organization, but it is uncertain to what extent they are essential for animal development. The Drosophila protein DSas-4 is related to the human microcephaly protein CenpJ and the C. elegans centriolar protein Sas-4.
Basto, Renata +6 more
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Centrioles are amplified in cycling progenitors of olfactory sensory neurons.
PLoS Biology, 2020 Olfaction in most animals is mediated by neurons bearing cilia that are accessible to the environment. Olfactory sensory neurons (OSNs) in chordates usually have multiple cilia, each with a centriole at its base. OSNs differentiate from stem cells in the
Kaitlin Ching, Tim Stearns
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LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation. [PDF]
Cytoskeleton (Hoboken)ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Peneda C +4 more
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Cellular Mechanisms of Ciliary Length Control
Cells, 2016 Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility ...
Jacob Keeling +2 more
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