Results 1 to 10 of about 12,547 (170)
Actin nucleation at the centrosome controls lymphocyte polarity
Nature Communications, 2016 Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al.
Dorian Obino +12 more
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Centrosome Remodelling in Evolution [PDF]
Cells, 2018 The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM).
D. Ito, M. Bettencourt-Dias
semanticscholar +4 more sources
The centrosome and cell proliferation
Cell Division, 2006 Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
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The Dictyostelium Centrosome [PDF]
Cells, 2021 The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf +4 more
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Nature Communications, 2021 Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes.
Guangjian Fan +16 more
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Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
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Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes
Cell Structure and Function, 2020 Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takumi Chinen +3 more
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Centrosome anchoring regulates progenitor properties and cortical formation
Nature, 2020 Radial glial progenitor cells (RGPs) are the major neural progenitor cells that generate neurons and glia in the developing mammalian cerebral cortex 1 – 4 .
W. Shao +11 more
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A catalog of numerical centrosome defects in epithelial ovarian cancers
EMBO Molecular Medicine, 2022 Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton +25 more
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Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome
bioRxiv, 2020 Centrosomes are composed of a centriolar core surrounded by a pericentriolar material (PCM) matrix that docks microtubule-nucleating γ-tubulin complexes.
Midori Ohta +7 more
semanticscholar +1 more source