Results 1 to 10 of about 74,905 (314)

Catalytic growth in a shared enzyme pool ensures robust control of centrosome size [PDF]

eLife
Accurate regulation of centrosome size is essential for ensuring error-free cell division, and dysregulation of centrosome size has been linked to various pathologies, including developmental defects and cancer.
Deb Sankar Banerjee, Shiladitya Banerjee
doaj   +2 more sources

Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo [PDF]

Scientific Reports
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus ...
Shayne M. Plourde, Natalia Kravtsova, Adriana T. Dawes   +2 more
doaj   +2 more sources

Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number

iScience, 2023
Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley, Rachel N. Yim, Joseph DiPanni, Brandon Sebou, Blake Shaffou, Evan Cramer, Colin Wu, Megan Kabara, Mi Hye Song   +8 more
doaj   +1 more source

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

A catalog of numerical centrosome defects in epithelial ovarian cancers

EMBO Molecular Medicine, 2022
Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto   +25 more
doaj   +1 more source

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]

PLoS ONE, 2014
Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee, Wan-Jen Hong, Ravindra Majeti, Tim Stearns   +3 more
doaj   +1 more source

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

iScience, 2023
Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang, Xianxiong Ma, Guanxin Wei, Xiuxian Zhu, Peng Hu, Xiang Chen, Dianshi Wang, Yuan Li, Tuo Ruan, Weikang Zhang, Kaixiong Tao, Chuanqing Wu   +11 more
doaj   +1 more source

Centrosome-phagy: implications for human diseases

Cell & Bioscience, 2021
Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments.
Qi Wu, Xin Yu, Le Liu, Shengrong Sun, Si Sun   +4 more
doaj   +1 more source

Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle

Cells, 2022
The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during ...
Fabiola Mascanzoni, Roberta Iannitti, Antonino Colanzi   +2 more
doaj   +1 more source

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source