Results 1 to 10 of about 74,831 (235)

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication [PDF]

Nature Communications
Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division.
Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata, Daiju Kitagawa   +12 more
doaj   +2 more sources

Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number

iScience, 2023
Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley, Rachel N. Yim, Joseph DiPanni, Brandon Sebou, Blake Shaffou, Evan Cramer, Colin Wu, Megan Kabara, Mi Hye Song   +8 more
doaj   +1 more source

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

A catalog of numerical centrosome defects in epithelial ovarian cancers

EMBO Molecular Medicine, 2022
Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto   +25 more
doaj   +1 more source

Centrosome-phagy: implications for human diseases

Cell & Bioscience, 2021
Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments.
Qi Wu, Xin Yu, Le Liu, Shengrong Sun, Si Sun   +4 more
doaj   +1 more source

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

iScience, 2023
Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang, Xianxiong Ma, Guanxin Wei, Xiuxian Zhu, Peng Hu, Xiang Chen, Dianshi Wang, Yuan Li, Tuo Ruan, Weikang Zhang, Kaixiong Tao, Chuanqing Wu   +11 more
doaj   +1 more source

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]

PLoS ONE, 2014
Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee, Wan-Jen Hong, Ravindra Majeti, Tim Stearns   +3 more
doaj   +1 more source

Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle

Cells, 2022
The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during ...
Fabiola Mascanzoni, Roberta Iannitti, Antonino Colanzi   +2 more
doaj   +1 more source

The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation

Cell Death and Disease, 2023
During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song, Yu Zhang, Yutong Li, Juntao Bie, Zhe Wang, Xin Yang, Haishuang Li, Liangyi Zhu, Tianzhuo Zhang, Qing Chang, Jianyuan Luo   +10 more
doaj   +1 more source

Emerging roles of centrosome cohesion

Open Biology, 2022
The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells.
Hairuo Dang, Elmar Schiebel
doaj   +1 more source