Results 51 to 60 of about 17,279 (253)
Journal of Cell Biology, 2016 Meitinger et al. perform a genome-wide CRISPR/Cas9 screen for centrinone resistance and identify a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.
Franz Meitinger +10 more
semanticscholar +1 more source
Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]
Molecular Cell, 2007 Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander +3 more
openaire +3 more sources
Multiscale polar theory of microtubule and motor-protein assemblies [PDF]
Phys. Rev. Lett. 114 (2015) 048101, 2014 Microtubules and motor proteins are building blocks of self-organized subcellular biological structures such as the mitotic spindle and the centrosomal microtubule array. These same ingredients can form new "bioactive" liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics.
arxiv +1 more source
A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex
Cells, 2020 The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan +2 more
doaj +1 more source
A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
Journal of Cell Biology, 2016 Lambrus et al. show that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Bramwell G. Lambrus +6 more
semanticscholar +1 more source
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. III. The role of flagellated cell fusion in the formation of the first animal and evolutionary clues to the Warburg effect [PDF]
arXiv, 2022 Cytasters have been underestimated in terms of their potential relevance to embryonic development and evolution. From the perspective discussed herein, structures such as the multiciliated cells of comb rows and balancers supporting mineralized statoliths and macrocilia in Beroe ovata point to a past event of multiflagellate fusion in the origin of ...
arxiv
Optimality of spatially inhomogeneous search strategies [PDF]
Phys. Rev. Lett. 117, 068101 (2016), 2016 We consider random search processes alternating stochastically between diffusion and ballistic motion, in which the distribution function of ballistic motion directions varies from point to point in space. The specific space dependence of the directional distribution together with the switching rates between the two modes of motion establishes a ...
arxiv +1 more source
Scientific Reports, 2023 Alterations in centrosome proteins may result in centrosome abnormalities such as disorganized spindles and centrosome amplification, leading to aneuploidy and genomic instability.
Laxmidhar Das
doaj +1 more source
Actin filaments regulate microtubule growth at the centrosome
bioRxiv, 2018 The centrosome is the main microtubule-organizing centre. It also organizes a local network of actin filaments. However, the precise function of the actin network at the centrosome is not well understood.
Daisuke Inoue +7 more
semanticscholar +1 more source
CCDC102B functions in centrosome linker assembly and centrosome cohesion [PDF]
Journal of Cell Science, 2018 ABSTRACT The proteinaceous centrosome linker is an important structure that allows the centrosome to function as a single microtubule-organizing center (MTOC) in interphase cells. However, the assembly mechanism of the centrosome linker components remains largely unknown.
Yuqing Xia +7 more
openaire +3 more sources