Results 1 to 10 of about 124,464 (285)

Ceramide remodeling and risk of cardiovascular events and mortality [PDF]

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl ...
Dorr, Marcus, Duncan, Meredith S, Felix, Stephan B, Friedrich, Nele, Gross, Stefan, Jiang, Hui, Jiang, Xuntian, Nauck, Matthias, Ory, Daniel S, Peterson, Linda R, Shaffer, Jean E, Sidhu, Rohini, Vasan, Ramachandran S, Volzke, Henry, Xanthakis, Vanessa   +14 more
core   +3 more sources

Advances in determining signaling mechanisms of ceramide and role in disease

Journal of Lipid Research, 2019
Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins.
Jeffrey L. Stith, Fabiola N. Velazquez, Lina M. Obeid   +2 more
doaj   +2 more sources

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]

OncoTarget, 2015
Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C, Baulies, A, Caballeria, J, Casas, J, Elena, M, Fabriàs, G, Fernandez-Checa, JC, García-Ruiz, C, Martinez Gili, L, Torres, S   +9 more
core   +3 more sources

Astrocytic ceramide as possible indicator of neuroinflammation

Journal of Neuroinflammation, 2019
Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder, Helga E. de Vries   +5 more
doaj   +2 more sources

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

Journal of Extracellular Vesicles, 2022
The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport of ceramide ...
Simone M Crivelli, Caterina Giovagnoni, Zhihui Zhu, P. Tripathi, A. Elsherbini, Zainuddin Quadri, Jian Pu, Lu Zhang, Branislav Ferko, D. Berkeš, Stefka D. Spassieva, P. Martinez-Martinez, E. Bieberich   +12 more
semanticscholar   +1 more source

The acid sphingomyelinase/ceramide system in COVID-19

Molecular Psychiatry, 2021
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry.
J. Kornhuber, N. Hoertel, E. Gulbins
semanticscholar   +1 more source

Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Ceramide accumulates in Parkinson’s disease–related PINK1 deficiency to initiate ceramide-mediated mitophagy as an alternative pathway to overcome defective PINK1-related mitophagy and the concomitant increased requirements for mitochondrial
M. Vos, Marija Dulovic-Mahlow, Frida Mandik, Lisa Frese, Yuliia Kanana, Sokhna Haissatou Diaw, Julia Depperschmidt, Claudia Böhm, Jonas Rohr, T. Lohnau, I. König, C. Klein   +11 more
semanticscholar   +1 more source

Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]

PLoS ONE, 2016
Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang, Yu Pan, Zhixiang Bian, Peihua Chen, Shijian Zhu, Huiyi Gu, Liping Guo, Chun Hu   +7 more
doaj   +1 more source

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation

Cells, 2022
Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the skin
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park   +4 more
doaj   +1 more source

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Nature Communications, 2020
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic ...
E. Johnson, S. L. Heaver, Jillian L. Waters, Benjamin I. Kim, A. Bretin, A. Goodman, A. Gewirtz, T. Worgall, R. Ley   +8 more
semanticscholar   +1 more source