Results 1 to 10 of about 82,164 (300)
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy [PDF]
Cell Reports, 2018 Summary: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear.
Stanley M. Walls +5 more
doaj +3 more sources
Advances in determining signaling mechanisms of ceramide and role in disease
Journal of Lipid Research, 2019 Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins.
Jeffrey L. Stith +2 more
doaj +2 more sources
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
Nature Communications, 2018 Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18
Nigel Turner, , Hamish D Toop
exaly +2 more sources
Mammalian ceramide synthases [PDF]
IUBMB Life, 2010 AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and ...
Anthony H Futerman
exaly +3 more sources
Astrocytic ceramide as possible indicator of neuroinflammation
Journal of Neuroinflammation, 2019 Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit +5 more
doaj +2 more sources
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy.
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer.
Javad Alizadeh +11 more
semanticscholar +1 more source
Journal of Extracellular Vesicles, 2022 The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport of ceramide ...
Simone M Crivelli +12 more
semanticscholar +1 more source
The acid sphingomyelinase/ceramide system in COVID-19
Molecular Psychiatry, 2021 Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry.
J. Kornhuber, N. Hoertel, E. Gulbins
semanticscholar +1 more source
Journal of Biological Chemistry, 2011 Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire +2 more sources
Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Ceramide accumulates in Parkinson’s disease–related PINK1 deficiency to initiate ceramide-mediated mitophagy as an alternative pathway to overcome defective PINK1-related mitophagy and the concomitant increased requirements for mitochondrial
Melissa Vos +11 more
semanticscholar +1 more source