Results 101 to 110 of about 124,464 (285)
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance [PDF]
, 2016 Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors.
Aja, Susan +7 more
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Characterization of genes involved in ceramide metabolism in the Pacific oyster (
BMC Research Notes, 2012 Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj +1 more source
Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death. [PDF]
, 2019 学位記番号 ...
Shibusawa, Ryo +2 more
core
Journal of Biological Chemistry, 2016 Ceramides are bioactive sphingolipids, which are composed of sphingoid bases carrying acyl chains of various lengths. Ceramides are synthesized by a family of six ceramide synthases (CerS) in mammals, which produce ceramides with different N-linked acyl ...
Dominic Gosejacob +8 more
semanticscholar +1 more source
Journal of Lipid Research, 1972 Methylation analysis of ceramide tetrasaccharide isolated from human erythrocytes gave acetates of 2,3,6-tri-O-methylgalactitol and 2,4,6-tri-O-methylgalactitol in a ratio of 1 : 1, and about 50% of the galactose was oxidized by periodate.
Bader Siddiqui +3 more
doaj +1 more source
Journal of Lipid Research, 2006 Ceramide is a component of the sphingomyelin cycle and a well-established lipid signaling molecule. We recently reported that ceramide specifically increased ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I), a critical process that leads ...
Amy B. Ghering, W. Sean Davidson
doaj +1 more source
Scientific Reports, 2016 Inhibition of stearoyl-CoA desaturase 1 (SCD1) has been found to effectively suppress tumor cell proliferation and induce apoptosis in numerous neoplastic lesions.
Ling Chen +9 more
semanticscholar +1 more source
Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]
, 2017 Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia +4 more
core +2 more sources
The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609
Journal of Lipid Research, 2004 The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de novo ceramide biosynthesis. However, the relationship between the intracellular site(s) of ceramide accumulation and cytotoxicity is poorly understood.
Ryan J. Perry, Neale D. Ridgway
doaj +1 more source
BMJ Open Diabetes Research & Care, 2020 Introduction Sphingolipid accumulation has been linked to obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). A recent study showed that depletion of dihydroceramide desaturase-1 (DES-1) in adipose and/or liver tissue decreases ...
Irene Esposito +8 more
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