Results 11 to 20 of about 124,464 (285)
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy [PDF]
Cell Reports, 2018 Summary: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear.
Stanley M. Walls +5 more
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Ceramide and Regulation of Vascular Tone [PDF]
International Journal of Molecular Sciences, 2019 In addition to playing a role as a structural component of cellular membranes, ceramide is now clearly recognized as a bioactive lipid implicated in a variety of physiological functions.
Á. Cogolludo +3 more
semanticscholar +7 more sources
Ceramide and ceramide 1-phosphate in health and disease [PDF]
Lipids in Health and Disease, 2010 AbstractSphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis.
Arana Urbieta, Lide +4 more
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Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification
Frontiers in Endocrinology, 2020 Ceramides are bioactive lipids that have an important role in many cellular functions such as apoptosis and inflammation. During the past decade emerging clinical data have shown that ceramides are not only of great biochemical interest but may also have
M. Hilvo +4 more
semanticscholar +1 more source
Journal of Biological Chemistry, 2011 Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire +2 more sources
Ceramides in Adipose Tissue [PDF]
Frontiers in Endocrinology, 2020 Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic ...
Bhagirath Chaurasia +3 more
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Ceramide in cerebrovascular diseases
Frontiers in Cellular Neuroscience, 2023 Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders.
Huiqi Yuan +3 more
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Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif.
PLoS ONE, 2022 The important membrane lipid, ceramide, is generated by a family of homologous enzymes, the ceramide synthases (CerSs), multi-spanning membrane proteins located in the endoplasmic reticulum.
Jiyoon Kim +4 more
doaj +3 more sources
The targeting of plasmalemmal ceramide to mitochondria during apoptosis. [PDF]
PLoS ONE, 2011 Ceramide is a key lipid mediator of cellular processes such as differentiation, proliferation, growth arrest and apoptosis. During apoptosis, ceramide is produced within the plasma membrane.
Eduard B Babiychuk +6 more
doaj +1 more source
Fermentation, 2019 Koji, which is used for manufacturing Japanese traditional fermented foods, has long been safely used as a cosmetic product. Although its cosmetic effect has been empirically established, the underlying mechanism has not been reported.
Miyuki Miyagawa +6 more
doaj +1 more source