Results 11 to 20 of about 82,164 (300)

Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]

PLoS ONE, 2016
Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang, Yu Pan, Zhixiang Bian, Peihua Chen, Shijian Zhu, Huiyi Gu, Liping Guo, Chun Hu   +7 more
doaj   +1 more source

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation

Cells, 2022
Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the skin
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park   +4 more
doaj   +1 more source

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Nature Communications, 2020
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic ...
E. Johnson, S. Heaver, Jillian L. Waters, Benjamin I. Kim, A. Bretin, A. Goodman, A. Gewirtz, T. Worgall, R. Ley   +8 more
semanticscholar   +1 more source

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

Cell Metabolism, 2013
Alexei Kharitonenkov
exaly   +2 more sources

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif

PLoS ONE, 2022
The important membrane lipid, ceramide, is generated by a family of homologous enzymes, the ceramide synthases (CerSs), multi-spanning membrane proteins located in the endoplasmic reticulum.
Jiyoon Kim, Yael Pewzner-Jung, Tammar Joseph, Shifra Ben-Dor, Anthony H. Futerman   +4 more
doaj   +2 more sources

The targeting of plasmalemmal ceramide to mitochondria during apoptosis. [PDF]

PLoS ONE, 2011
Ceramide is a key lipid mediator of cellular processes such as differentiation, proliferation, growth arrest and apoptosis. During apoptosis, ceramide is produced within the plasma membrane.
Eduard B Babiychuk, Alexander P Atanassoff, Katia Monastyrskaya, Christina Brandenberger, Daniel Studer, Catherine Allemann, Annette Draeger   +6 more
doaj   +1 more source

Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification

Frontiers in Endocrinology, 2020
Ceramides are bioactive lipids that have an important role in many cellular functions such as apoptosis and inflammation. During the past decade emerging clinical data have shown that ceramides are not only of great biochemical interest but may also have
M. Hilvo, V. Vasile, L. Donato, R. Hurme, R. Laaksonen   +4 more
semanticscholar   +1 more source

Glycosylceramides Purified from the Japanese Traditional Non-Pathogenic Fungus Aspergillus and Koji Increase the Expression of Genes Involved in Tight Junctions and Ceramide Delivery in Normal Human Epidermal Keratinocytes

Fermentation, 2019
Koji, which is used for manufacturing Japanese traditional fermented foods, has long been safely used as a cosmetic product. Although its cosmetic effect has been empirically established, the underlying mechanism has not been reported.
Miyuki Miyagawa, Ayami Fujikawa, Mayu Nagadome, Kanae Kohama, Takatoshi Ogami, Seiichi Kitamura, Hiroshi Kitagaki   +6 more
doaj   +1 more source

Brain ceramide hexosides in Tay-Sachs disease and generalized gangliosidosis (GM1-gangliosidosis)

Journal of Lipid Research, 1967
The carbohydrate composition was determined for ceramide hexosides isolated from brains of patients with Tay-Sachs disease and generalized gangliosidosis (hereby named GM1-gangliosidosis).Gray matter of patients with each disease showed a characteristic ...
Kunihiko Suzuki, Gloria C. Chen
doaj   +1 more source

Long chain ceramides raise the main phase transition of monounsaturated phospholipids to physiological temperature

Scientific Reports, 2022
Little is known about the molecular mechanisms of ceramide-mediated cellular signaling. We examined the effects of palmitoyl ceramide (C16-ceramide) and stearoyl ceramide (C18-ceramide) on the phase behavior of 1-palmitoyl-2-oleoyl-sn-glycero-3 ...
Hiroshi Takahashi, Tomohiro Hayakawa, Asami Makino, Kunihiko Iwamoto, Kazuki Ito, Satoshi B. Sato, Toshihide Kobayashi   +6 more
doaj   +1 more source