Results 11 to 20 of about 110,293 (352)

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress

International Journal of Oral Science, 2021
C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen, Chenzhou Wu, Yafei Chen, Yuhao Guo, Ling Qiu, Zhe Liu, Haibin Sun, Siyu Chen, Zijian An, Zhuoyuan Zhang, Yi Li, Longjiang Li   +11 more
doaj   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins

Journal of Lipid Research, 2008
Increased mitochondrial ceramide levels are associated with the initiation of apoptosis. There is evidence that ceramide is causal. Thus, the conversion of the precursor, dihydroceramide, to ceramide by the enzyme dihydroceramide desaturase may be ...
Johnny Stiban, Laura Caputo, Marco Colombini   +2 more
doaj   +1 more source

Ceramide is a Mediator of Apoptosis in Retina Photoreceptors [PDF]

, 2006
PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this death in photoreceptors.
Abrahan, Carolina Elizabeth, German, Olga Lorena, Miranda, Gisela Edit, Rotstein, Nora Patricia   +3 more
core   +1 more source

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

Ceramide remodeling and risk of cardiovascular events and mortality [PDF]

, 2018
BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl ...
Dorr, Marcus, Duncan, Meredith S, Felix, Stephan B, Friedrich, Nele, Gross, Stefan, Jiang, Hui, Jiang, Xuntian, Nauck, Matthias, Ory, Daniel S, Peterson, Linda R, Shaffer, Jean E, Sidhu, Rohini, Vasan, Ramachandran S, Volzke, Henry, Xanthakis, Vanessa   +14 more
core   +2 more sources

Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury

JCI Insight, 2023
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear.
Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny V. Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick   +13 more
doaj   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]

, 2012
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ, Brock, R, Cluitmans, JC, Dinkla, S, Fransen, J, Fuchs, B, Joosten, I, Schiller, J, Tomelleri, C, Verdurmen, WP, Wessels, K   +10 more
core   +1 more source

Development and characterization of a novel anti-ceramide antibody

Journal of Lipid Research, 2007
Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Kannan Krishnamurthy, Somsankar Dasgupta, Erhard Bieberich   +2 more
doaj   +1 more source