Results 21 to 30 of about 82,164 (300)

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress

International Journal of Oral Science, 2021
C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen, Chenzhou Wu, Yafei Chen, Yuhao Guo, Ling Qiu, Zhe Liu, Haibin Sun, Siyu Chen, Zijian An, Zhuoyuan Zhang, Yi Li, Longjiang Li   +11 more
doaj   +1 more source

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Science, 2019
Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which are the true culprits underlying metabolic ...
Bhagirath Chaurasia, Trevor S. Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L. Wilkerson, C. Sweeney, R. F. Pereira, D. H. Sumida, J. Maschek, J. Cox, V. Kaddai, G. Lancaster, M. M. Siddique, Annelise M. Poss, Mackenzie J. Pearson, S. Satapati, Heather H. Zhou, D. McLaren, S. Previs, Ying Chen, Y. Qian, Aleksandr Petrov, Margaret S. Wu, Xiaolan Shen, Jun Yao, Christian N. Nunes, A. Howard, Liangsu Wang, M. Erion, J. Rutter, J. Rutter, W. Holland, D. Kelley, S. Summers   +35 more
semanticscholar   +1 more source

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins

Journal of Lipid Research, 2008
Increased mitochondrial ceramide levels are associated with the initiation of apoptosis. There is evidence that ceramide is causal. Thus, the conversion of the precursor, dihydroceramide, to ceramide by the enzyme dihydroceramide desaturase may be ...
Johnny Stiban, Laura Caputo, Marco Colombini   +2 more
doaj   +1 more source

Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury

JCI Insight, 2023
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear.
Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny V. Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick   +13 more
doaj   +1 more source

Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients.

European Heart Journal, 2019
AIMS Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ceramides with ...
M. Hilvo, P. Meikle, E. Pedersen, G. Tell, I. Dhar, H. Brenner, B. Schöttker, Mitja Lääperi, Dimple Kauhanen, K. Koistinen, A. Jylhä, K. Huynh, N. Mellett, A. Tonkin, D. Sullivan, J. Simes, P. Nestel, W. Koenig, D. Rothenbacher, O. Nygård, R. Laaksonen   +20 more
semanticscholar   +1 more source

Development and characterization of a novel anti-ceramide antibody

Journal of Lipid Research, 2007
Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Kannan Krishnamurthy, Somsankar Dasgupta, Erhard Bieberich   +2 more
doaj   +1 more source

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

Journal of Pharmacological Sciences, 2010
.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama   +7 more
doaj   +1 more source

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]

PLoS ONE, 2013
Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland, Ushma A Doshi, Sriram S Shanmugavelandy, Todd E Fox, Cesar Aliaga, Kathleen Broeg, Kendall Thomas Baab, Megan Young, Osman Khan, Jeremy K Haakenson, Nancy Ruth Jarbadan, Jason Liao, Hong-Gang Wang, David J Feith, Thomas P Loughran, Xin Liu, Mark Kester   +16 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source