Results 51 to 60 of about 124,464 (285)

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi, A Gray, A Kowluru, A Kowluru, A Soto-Guzman, Alexander Gray, B Xue, C Schmitz-Peiffer, Christopher Lipina, CL Kien, CL Kien, CL Kien, CM Blouin, D Fedor, David Magill, DJ Powell, DJ Powell, E Hajduch, Eric Hajduch, Francesca Nardi, G Boden, H Cao, Harinder S. Hundal, J Chen, JA Chavez, JT Vilquin, Juergen Eckel, K Macrae, KD Copps, L Salvado, L Yuzefovych, LG Gillingham, M Andjelkovic, M Parillo, MM Bradford, MR Junttila, N Dimopoulos, P Seshacharyulu, PJ Eichhorn, R Cazzolli, R Hage Hassan, RA DeFronzo, Rima Hage Hassan, S Stratford, S Turban, SE Kahn, T Coll, T Galbo, T Galbo, V Janssens, XT Feng, Y Mitsumoto, Y Wu   +52 more
core   +13 more sources

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Frontiers in Cell and Developmental Biology, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang, Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Liansheng Zhong, Ahmed Elsherbini, Sanjib Karki, Simone M. Crivelli, Wenbo Zhi, Guanghu Wang, Stefanka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

The ART of Lowering Ceramides [PDF]

Cell Metabolism, 2015
Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipidaemia and obesity. Using a genetic mouse model to acutely degrade ceramides in adipose tissue or the liver (i.e., by conditionally expressing acid ceramidase), in this issue of Cell MetabolismXia et al. (2015) identify roles for these molecules in insulin
openaire   +3 more sources

Detergent-Resistant, Ceramide-Enriched Domains in Sphingomyelin/Ceramide Bilayers [PDF]

Biophysical Journal, 2006
When cell membranes are treated with Triton X-100 or other detergents at 4 degrees C, a nonsolubilized fraction can often be recovered, the "detergent-resistant membranes", that is not found when detergent treatment takes place at 37 degrees C. Detergent-resistant membranes may be related in some cases to membrane "rafts".
Sot, Jesus, Bagatolli, Luis, Goñi, Felix Maria, Alonso, Alicia   +3 more
openaire   +7 more sources

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Nature Communications, 2018
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18
N. Turner, X. Y. Lim, H. Toop, B. Osborne, A. Brandon, Elysha N. Taylor, Corrine E. Fiveash, H. Govindaraju, Jonathan D Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M Butler, Abhirup Das, Greg M. Kowalski, C. Bruce, Kyle L. Hoehn, T. Fath, C. Schmitz‐Peiffer, G. Cooney, M. Montgomery, Jonathan C. Morris, A. Don   +21 more
semanticscholar   +1 more source

Developmental Comparison of Ceramide in Wild-Type and Cln3Δex7/8 Mouse Brains and Sera

Frontiers in Neurology, 2019
CLN3 disease is a neurodevelopmental disease leading to early visual failure, motor decline, and death. CLN3 pathogenesis has been linked to dysregulation of ceramide, a key intracellular messenger impacting various biological functions.
Sally El-Sitt, Jihane Soueid, Jamal Al Ali, Joelle Makoukji, Nadine J. Makhoul, Hayat Harati, Rose-Mary Boustany   +6 more
doaj   +1 more source

Ceramide mediates radiation-induced germ cell apoptosis via regulating mitochondria function and MAPK factors in Caenorhabditis elegans

Ecotoxicology and Environmental Safety, 2021
Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living
Yaning Yang, Guangmin Xu, Yun Xu, Xiaowen Cheng, Shengmin Xu, Shaopeng Chen, Lijun Wu   +6 more
doaj   +1 more source

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. [PDF]

, 2019
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Chang, Nai-Chuan, Chen, I-Ju, Ho, Ching-Liang, Lai, Tai-Yu, Lee, Andy Chi-Lung, Liao, Guo-Shiou, Lin, Ruey-Jen, Wu, Jen-Chine, Yeo, Hui-Ling, Yu, Alice L   +9 more
core   +2 more sources