Results 151 to 160 of about 4,583,316 (255)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The Analysis of ceRNA Networks and Tumor Microenvironment in Endometrial Cancer

Journal of Cancer
Background: Endometrial carcinoma is a life-threatening and aggressive tumor that affects women worldwide. ceRNAs and carcinoma-infiltrating immunocytes can be associated with tumor formation and progression. Therefore, investigating the unique mechanisms underlying endometrial carcinoma is crucial.
Huang, Jian, Yang, Xiaoyue, Xu, Shen, Li, Ping   +3 more
openaire   +2 more sources

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1913-1927, October 2026.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, Volume 101, Issue 5, Page 2214-2239, October 2026.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source

ceRNA networks in ischemic stroke: a bibliometric analysis

Egyptian Journal of Medical Human Genetics
Abstract Background and method Ischemic stroke, a leading cause of death and disability worldwide, has been increasingly linked to ceRNA networks, which regulate neuronal damage and recovery. Despite growing interest, a comprehensive bibliometric analysis of ceRNA’s role in stroke remains limited.
Loo Keat Wei, Lyn R. Griffiths, Trygve O. Tollefsbol   +2 more
openaire   +2 more sources

MOESM4 of Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma

, 2019
Additional file 4: Table S4.
Li He (134049), Yi Bai (450166), Xu Yang (112496), Jianzhen Lin (5568209), Yongchang Zheng (701580), Xiaobo Yang (123393), Haitao Zhao (14023), Dongxu Wang (2562808), Junyu Long (5568212)   +8 more
core   +1 more source

The Role of Noncoding RNA in MGMT‐Positive Glioblastoma: A Narrative Review

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant tumor of the central nervous system and is characterized by rapid progression, frequent recurrence, and poor survival outcomes. The current standard of care, comprising maximal safe surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ), has ...
Junfeng Zhao, Jiaxuan Chen, Yingrui Bai, Ying Li, Yiming Han, Chuankun Han, Yintao Li   +6 more
wiley   +1 more source

Additional file 2: Figure S2. of Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

, 2017
Complete ceRNA interaction network. (A) ceRNA interaction network constructed by merging 537,304 significant ceRNA triplets (P 
Yu-Chiao Chiu (113875), Tzu-Hung Hsiao (403747), Yidong Chen (11610), Tzu-Pin Lu (145405), Li-Ju Wang (547385), Eric Chuang (26623)   +5 more
core   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source