Results 161 to 170 of about 4,583,316 (255)

Fingolimod Alleviates Neuroinflammation and Blood–Brain Barrier Disruption in Epilepsy by Upregulating S1PR5 and Inhibiting the Rho/ROCK/NF‐κB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Fingolimod alleviates epilepsy by restoring S1PR5 expression and suppressing the Rho/ROCK/NF‐κB pathway, thereby reducing neuroinflammation, preserving blood–brain barrier integrity, and attenuating seizure activity. ABSTRACT Objective This study aimed to clarify the role of sphingosine‐1‐phosphate receptor 5 (S1PR5) in epileptic pathogenesis and the ...
Chen Zhang, Yanli Duan, Mengmeng Ma, Lin Xu, Wei‐Na Jin, Zhuoran Zhang   +5 more
wiley   +1 more source

Transcriptomic profiling reveals conserved stage‐associated programs across gastrointestinal adenocarcinomas

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Abstract Background Gastrointestinal (GI) adenocarcinomas exhibit substantial molecular heterogeneity despite their shared epithelial origin and anatomical continuity. Whether these anatomically distinct cancers share conserved transcriptomic programs associated with pathological stage remains unclear.
Wynston Jay Abenojar, Ron Jacob Avila, Po‐Wei Tsai, Lemmuel Tayo   +3 more
wiley   +1 more source

Integrative Network Analysis and Machine Learning Identify Cell Adhesion‐Related Biomarkers and Immune Heterogeneity in Allergic Rhinitis

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Allergic rhinitis (AR) represents a highly prevalent inflammatory disorder of the nasal mucosa, but molecular indicators capable of capturing its disease‐specific transcriptional features remain insufficiently defined. This study aimed to identify cell adhesion‐related diagnostic biomarkers for AR and to investigate their immune ...
Guoshun He, Liying Zhang
wiley   +1 more source

Integrative analysis of the lncRNA-associated ceRNA network reveals lncRNAs as potential prognostic biomarkers in human muscle-invasive bladder cancer

Cancer Management and Research, 2019
Lei Lyu, Wei Xiang, Jin-Yan Zhu, Tao Huang, Jing-Dong Yuan, Chuan-Hua ZhangDepartment of Urology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People’s Republic of ...
Lyu L, Xiang W, Zhu JY, Huang T, Yuan JD, Zhang CH   +5 more
doaj  

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma

Scientific Reports
Prostate cancer (PCa) ranks among the most prevalent malignant tumors worldwide. The pivotal role of competitive endogenous RNA (ceRNA) regulatory networks in numerous cancer types has been underscored.
Zhi Shang, Shengming Jin, Yandong He, Yiping Zhu, Hailiang Zhang, Junlong Wu, Zhe Hong, Dingwei Ye   +7 more
doaj   +1 more source

Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy

Brain Research Bulletin
Background: medial temporal lobe epilepsy (mTLE) is among the most common types of temporal lobe epilepsy (TLE) ，it is generally resistant to drug treatment, which significantly impacts the quality of life and treatment.
Bingzheng Gong, Mian Li, Ziru Wang, Gulingyue Hao, Liang Sun, Jingjun Zhang, Liangjie Yuan   +6 more
doaj   +1 more source

LINC01352 Inhibits Lung Adenocarcinoma Progression by Modulating the miR‐425‐5p/SRSF11 Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
LINC01352 exhibits tumor‐suppressive activity in LUAD through the miR‐425‐5p/SRSF11 axis, thereby inhibiting LUAD malignant progression. Our study suggests that targeting the LINC01352/miR‐425‐5p/SRSF11 pathway may represent a promising therapeutic strategy for LUAD. ABSTRACT Lung adenocarcinoma (LUAD), as the most common subtype of non‐samll cell lung
Xiaoxiao Ma, Ling Liu, Fang Fang
wiley   +1 more source

Systems biology analysis of long non-coding RNAs and targets to identify key modules and biomarkers in breast cancer

Discover Oncology
Objective The objective of this study is to elucidate the breast cancer (BC)-associated ceRNA regulatory network by examining the expression profiles of lncRNAs, miRNAs, and mRNAs. Methods Using RNA sequencing data from The Cancer Genome Atlas (TCGA), we
Chao Ma, Xueling Zhang, Rui Zhang, Hanteng Yang, Junling Wang, Chengyun Li   +5 more
doaj   +1 more source

SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei, Seyed Shahram Miraghaee, Faegheh Farhadi, Abolfazl Akbarzadeh, Fatemeh Yarmohammadi   +4 more
wiley   +1 more source