Results 101 to 110 of about 1,781 (177)

Association between CLN3 (Neuronal Ceroid Lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients

Frontiers in Oncology, 2015
Breast cancer is the most common cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes.
Rose-Mary eBoustany, Joelle eMakoukji, Mohamad eRaad, Katia eGenadry, Sally eEl-Sitt, Nadine J. Makhoul, Ehab eSaad Aldin, Eden eNohra, Mark eJabbour, Ajanthah eSangaralingam, Claude eChelala, Robert H. Habib, Fouad eBoulos, Arafat eTfayli   +13 more
doaj   +1 more source

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

, 2018
Colitis, an inflammatory disease of the digestive tract, is increasing in incidence and prevalence. Intestinal inflammation can occur as a consequence of dysfunctions in sphingolipid metabolism. In this study we used ceramide synthase 6 (CerS6) deficient
Besim Ogretmen, Peggi Angel, Kristi Helke, Elizabeth Garrett-Mayer, Richard Drake, Ping Lu, Christina Voelkel-Johnson   +6 more
core   +1 more source

Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses

Annals of Clinical and Translational Neurology, 2018
Objective Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease‐modifying drug candidates, with potential to enhance ...
Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El‐Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C. Trippier, Rose‐Mary Boustany   +7 more
doaj   +1 more source

The transcriptional landscape of luminal B subtype breast cancer in humans: CERS6.

Breast cancer in humans is a solid tumor type with distinct subtypes historically defined by the PAM50 molecular subtype classification scheme (1-3). We utilize, in this study, whole transcriptome technologies to define the transcriptional landscape of luminal B subtype human breast cancer (4, 5).
openaire   +2 more sources

Short-term respiratory cadmium exposure causes pulmonary function decline accompanied by upregulation of sphingolipid synthesis in mouse lungs

Environment International
Cadmium (Cd) is a respiratory toxicant. Previous reports have confirmed that chronic respiratory Cd exposure causes chronic obstructive pulmonary disease-like lesions in a murine model. This study aimed to evaluate the influence of short-term Cd exposure
Zhu-Xia Tan, Xue Lu, Hao-Yu Liao, Ya-Xin Yao, Zhi-Bing Liu, Nan-Nan Liang, Hui Zhao, Hua Wang, De-Xiang Xu   +8 more
doaj   +1 more source

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

, 2019
The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but is also crucial for lipid synthesis and metabolism. In the current study, we demonstrate an important role of ceramide synthases (CerS) in ER stress and NAFLD ...
박주원
core   +1 more source

Chemical Profile and Promising Applications of Cucurbita pepo L. Flowers

Antioxidants
Although edible flowers have been historically principally used due to their visual appeal and smell, the world is discovering their value as innovative and natural sources of bioactive compounds. Cucurbita pepo L.
Ritamaria Di Lorenzo, Luigi Castaldo, Raffaele Sessa, Lucia Ricci, Eleonora Vardaro, Luana Izzo, Michela Grosso, Alberto Ritieni, Sonia Laneri   +8 more
doaj   +1 more source

Hepatic inflammatory cytokine production can be regulated by modulating sphingomyelinase and ceramide synthase 6

, 2018
Chronic inflammation is associated with the pathogenesis of type 2 diabetes and diabetic complications, and palmitate has been nominated as a candidate for the molecular link between these disorders.
박주원
core   +1 more source

Additional file 1: Table S1. of Regulatory network reconstruction reveals genes with prognostic value for chronic lymphocytic leukemia

, 2016
Total list of genes with statistically significant differences obtained from the meta-analysis. Table S2. Selected regulators (CERS6, TCF7, and MYBL1) and their targets.
Liliana LĂłpez-Kleine (3493766), Sally Yepes (794040), Maria Torres (179041)   +2 more
core   +1 more source

Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

, 2013
Aims/hypothesis: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid.
Diakanastasis, B., Saville, J.T., Schmitz-Peiffer, C., Mitchell, T.W., Frangioudakis, G., Liao, B.Q.M., Hoffman, N.J.   +6 more
core   +1 more source