Results 91 to 100 of about 1,781 (177)

Structural basis of the mechanism and inhibition of a human ceramide synthase. [PDF]

Nat Struct Mol Biol
Ceramides are bioactive sphingolipids crucial for regulating cellular metabolism. Ceramides and dihydroceramides are synthesized by six ceramide synthase (CerS) enzymes, each with specificity for different acyl-CoA substrates.
Pascoa TC, Pike ACW, Tautermann CS, Chi G, Traub M, Quigley A, Chalk R, Štefanić S, Thamm S, Pautsch A, Carpenter EP, Schnapp G, Sauer DB.   +12 more
europepmc   +2 more sources

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source

Ceramide Synthase 2 Interacts with Ceramide Synthases 5 and 6 at the mRNA and Protein Levels [PDF]

, 2020
Ceramides and sphingolipids make up major portions of the plasma membrane and therefore are crucial for cell proliferation, survival, and death. With dysregulation comes numerous pathophysiological conditions, such as Alzheimer\u27s, Huntington\u27s ...
Yen, Dorothy
core   +1 more source

Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation

Journal of Lipid Research, 2017
Ceramides (Cers) and complex sphingolipids with defined acyl chain lengths play important roles in numerous cell processes. Six Cer synthase (CerS) isoenzymes (CerS1–6) are the key enzymes responsible for the production of the diversity of molecular ...
Lucila Gisele Pescio, Bruno Jaime Santacreu, Vanina Gisela Lopez, Carlos Humberto Paván, Daniela Judith Romero, Nicolás Octavio Favale, Norma Beatriz Sterin-Speziale   +6 more
doaj   +1 more source

Neutrophil-mediated macrophage responses to biodegradable magnesium and zinc implants

Journal of Magnesium and Alloys
Magnesium (Mg)- and zinc (Zn)-based biodegradable metals are increasingly used as bone-related implants. However, the early immune response, particularly neutrophil–macrophage crosstalk, remains poorly understood.
Jiannan Zhou, Yili Zhao, Wenyan Zhan, Qingyang Yan, Chen Zhu, Xiaokun Yang, An Li, Jingtao Dai, Yageng Li, Ping Li   +9 more
doaj   +1 more source

Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken

Poultry Science
To investigate the effect of fresh corn extract (FCE) on chicken meat quality, 135-day-old Jingyuan chicken hens were fed diets containing different doses of FCE (CON, 0.3% FCE, 0.6% FCE and 0.9% FCE) until 180 day-old in this study.
Jinli Tian, Yanxu Wu, Wei Zhao, Guojun Zhang, Hu Zhang, Lin Xue, Lijuan Yang, Tong Zhang, Yaling Gu, Juan Zhang   +9 more
doaj   +1 more source

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation

Frontiers in Psychiatry, 2018
Chronic psychosocial stress adversely affects human morbidity and is a risk factor for inflammatory disorders, liver diseases, obesity, metabolic syndrome, and major depressive disorder (MDD).
Martin Reichel, Martin Reichel, Cosima Rhein, Lena M. Hofmann, Juliana Monti, Lukasz Japtok, Dominik Langgartner, Andrea M. Füchsl, Andrea M. Füchsl, Burkhard Kleuser, Erich Gulbins, Claus Hellerbrand, Stefan O. Reber, Johannes Kornhuber   +13 more
doaj   +1 more source

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

, 2021
Lee W-K, MaaSS M, Quach A, et al. Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. Journal of Biological Chemistry.
Prangley, Holly, Ogretmen, Besim, Quach, Amy, Futerman, Anthony H, Poscic, Nataliya, Lee, Wing-Kee, Pierce, Jason S, MaaSS, Michelle, Thévenod, Frank, Pallott, Erin-Claire, Kim, Jiyoon L   +10 more
core   +1 more source

CD36 deficiency protects lipopolysaccharide-induced sepsis via inhibiting CerS6-mediated endoplasmic reticulum stress

International Immunopharmacology
The type 2 scavenger receptor CD36 functions not only as a long chain fatty acid transporter, but also as a pro-inflammatory mediator. Ceramide is the simple N-acylated form of sphingosine and exerts distinct biological activity depending on its acyl chain length.
Min Hee Kim, Hyomin Lim, Ok-Hee Kim, Byung-Chul Oh, YunJae Jung, Kyung-Ha Ryu, Joo-Won Park, Woo-Jae Park   +7 more
openaire   +2 more sources

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis

, 2017
Sphingolipids regulate critical cellular processes including inflammation. Ceramide, which serves a central role in sphingolipid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate specificity.
Besim Ogretmen, Matthew J. Scheffel, Jacob S. Bowers, Kristi Helke, Elizabeth Garrett-Mayer, Ping Lu, Chrystal M. Paulos, Christina Voelkel-Johnson   +7 more
core   +1 more source