Results 81 to 90 of about 1,781 (177)

Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Women with overweight or obesity follow intended isocaloric early and late time‐restricted eating (TRE) in a crossover trial. Shotgun plasma lipidomics reveals no significant differences between interventions, but identify pronounced lipid changes—including reductions in ceramides and phosphatidylcholines—within the early TRE.
Kristof Szekely, Mathias J. Gerl, Beeke Peters, Julia Schwarz, Bettina Schuppelius, Markus Damm, Jorge R. Soliz‐Rueda, Ratika Sehgal, Michail Lazaratos, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer, Annette Schürmann, Achim Kramer, Andreas Michalsen, Olga Pivovarova‐Ramich   +15 more
wiley   +1 more source

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

Journal of Lipid Research, 2012
Sphingolipids are not only important components of membranes but also have functions in protein trafficking and intracellular signaling. The LCB1 gene encodes a subunit of the serine palmitoyltransferase, which is responsible for the first step of ...
Sharon Epstein, Clare L. Kirkpatrick, Guillaume A. Castillon, Manuel Muñiz, Isabelle Riezman, Fabrice P.A. David, Claes B. Wollheim, Howard Riezman   +7 more
doaj   +1 more source

Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4

Computers in Biology and Medicine
Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated with this adverse reaction.In this study, a combination of interpretable neural networks and Generative Adversarial ...
Ali Arab, Bahareh Kashani, Miguel Cordova-Delgado, Erika N. Scott, Kaveh Alemi, Jessica Trueman, Gabriella Groeneweg, Wan-Chun Chang, Catrina M. Loucks, Colin J.D. Ross, Bruce C. Carleton, Martin Ester   +11 more
openaire   +3 more sources

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts. [PDF]

, 2015
Stichoposide D (STD) is a marine triterpene glycoside isolated from sea cucumbers. We examined the molecular mechanisms underlying the antitumor activity of STD in human leukemia cells.
Ju, MH, Han, JY, Kwak, JY, Stonik, VA, Park, JI, Park, ES, Shin, SW, Kim, SH, Jeong, JS, Yun, SH   +9 more
core   +1 more source

Revisiting tricuspid regurgitation: Historical insights and emerging research perspectives

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Tricuspid regurgitation (TR), once seen as benign, is now recognized as a serious and increasingly prevalent condition linked to aging and better imaging. Its association with greater morbidity and mortality has shifted clinical perspectives towards early diagnosis and intervention.
Claudia Gonzalez‐Cucharero, Gemma Vilahur, Marta Saura, Rocío Hinojar, Jose L. Zamorano, Carlos Zaragoza   +5 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells

, 2021
Polyploid giant cancer cells (PGCC) constitute a transiently senescent subpopulation of cancer cells that arises in response to stress. PGCC are capable of generating progeny via a primitive, cleavage-like cell division that is dependent on the ...
Besim Ogretmen, Gyda Beeson, James Norris, Craig Beeson, Ping Lu, Christina Voelkel-Johnson, Shai White-Gilbertson   +6 more
core   +1 more source

Impact of Nutrition on Sphingolipid‐Regulated Physiology: A Review

Molecular Nutrition &Food Research, Volume 69, Issue 20, October 2025.
Sphingolipids (SLs) play a role in multiple, if not all physiological processes. This review summarizes the current knowledge on SLs and their role in (patho‐) physiological processes with special regard to dietary and transgenerational effects. Image was created with BioRender.com.
Jonas Voß, Thorsten Hornemann, Bengt‐Frederik Belgardt   +2 more
wiley   +1 more source

Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies[S]

Journal of Lipid Research, 2010
Ceramides (Cers) are important in embryogenesis, but no comprehensive analysis of gene expression for Cer metabolism nor the Cer amounts and subspecies has been conducted with an often used model: mouse embryonic stem cells (mESCs) versus embroid bodies (
Hyejung Park, Christopher A. Haynes, Alison V. Nairn, Michael Kulik, Stephen Dalton, Kelley Moremen, Alfred H. Merrill, Jr.   +6 more
doaj   +1 more source