Results 61 to 70 of about 1,781 (177)
, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron (11652577) +2 more
core +1 more source
, 2022 S.326-335Ceramides (Cer) are mediators of inflammatory processes. In a chronic experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), we observed a significant elevation of C16-Cer and its synthesizing enzyme, ceramide synthase(
Willecke, K. +12 more
core +2 more sources
The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada +8 more
wiley +1 more source
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
Effects of MTX on CerS6, ceramide levels and cellular proliferation.
, 2016 (A) Levels of CerS6 (Western blot) in cancer cells with and without MTX treatment. Cells were collected 48 h after MTX was added. (B) Changes in CerS6 levels after treatment with 10 nM MTX for 48 h (calculated from A).
Natalia I. Krupenko (439696) +3 more
core +1 more source
Ceramide Synthase 6 in metabolic response to dietary fat and folic acid [PDF]
, 2020 Ceramides, a class of bioactive lipids, are important regulators of cellular metabolism mediating response to nutrient stress. Recent work from our laboratory demonstrated that, in cultured cells, folate stress response is mediated by ceramide synthase 6
Barron, Keri
core +1 more source
Cell Death and Disease, 2022 Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type with an extremely poor prognosis due to abundant vasculature.
Xuehong Wang +8 more
doaj +1 more source
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 846-858, April 2026.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
Histology and histopathology, 2022 Cervical cancer (CC) is a common disease in women characterized by high recurrence rate. LncRNA ceramide synthase 6 antisense RNA 1 (CERS6-AS1) has been found to play a crucial role in the progression of breast cancer and pancreatic cancer. Nevertheless, the regulatory role of CERS6-AS1 in CC remains largely unclear.
Yan, Kun +6 more
openaire +2 more sources
Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.Schematic model of the potential mechanisms by which physical exercise alleviates stress‐induced vascular inflammation via the BDNF–Kif4–TARM1 axis, revealing a neuroimmune‐mediated brain–heart axis that supports exercise therapy for psychogenic coronary artery disease. This graphical abstract was drawn with the FigDraw tool (www.fgdraw.com).
Xianghui Zheng +17 more
wiley +1 more source