Results 41 to 50 of about 1,781 (177)
American Journal of Physiology-Cell Physiology, 2023 This article addresses the roles of ceramide synthase 6 ( CERS6) and CERS6-derived ceramides in renal tubular epithelial cells of diabetic kidney disease (DKD) associated interstitial fibrosis. Results from knockdown of CERS6 adjusted the ceramide pool in kidney cortex and markedly protected from diabetic-induced kidney fibrosis in vivo and in vitro ...
Xiangyu Wang +16 more
openaire +2 more sources
Байкальский медицинский журнал, 2023 Introduction. Ceramides are bioactive lipids that are not only structural components of cell membranes, but also second messengers in the transmission of cell signals.
Julia Alexandrovna Dyleva +5 more
doaj +1 more source
Cell Reports, 2021 Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function.
Silvia Vaena +14 more
doaj +1 more source
, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron (11652577) +2 more
core +1 more source
Proposed two-step mechanism for CerS6-dependent MTX cytotoxicity.
, 2016 Step 1: MTX induces p53, which functions as the transcriptional activator of CerS6 and increases levels of the protein in ER. Step 2: MTX induces ER stress leading to aggregation of CerS6-containing ER membranes.
Natalia I. Krupenko (439696) +3 more
core +1 more source
, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron (11652577) +2 more
core +1 more source
, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron (11652577) +2 more
core +1 more source
Frontiers in Genetics, 2021 Sheep (Ovis aries) is one of the important livestock with diverse phenotypic traits. However, little is known about the molecular mechanism of diverse phenotypic traits in domestic sheep.
Song-Song Xu +4 more
doaj +1 more source
Targeting of CerS6 by MTX is p53-dependent.
, 2016 (A) MTX (10 nM) treatment strongly elevates CerS6 in p53+/+ but not p53-/- cells. (B) Antifolate lometrexol (LTX) bypasses p53 and does not affect CerS6: left panel, LTX inhibits both p53+/+ and p53-/- A549 cells (Experiments were performed three times ...
Natalia I. Krupenko (439696) +3 more
core +1 more source
, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron (11652577) +2 more
core +1 more source