Results 21 to 30 of about 1,781 (177)

Integrated clinical and PBMC transcriptomic profiling identifies lipid metabolism-related candidate signatures associated with chronic brucellosis [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectivesTo investigate clinical and peripheral blood mononuclear cells (PBMCs) transcriptomic features associated with chronic brucellosis and to test the hypothesis that lipid metabolism-related transcriptomic alterations in PBMCs may be involved in ...
Rong Wang, Rong Wang, Bin Niu, Bin Niu, Xin Zhang, Xin Zhang, Yinghan Wang, Yinghan Wang, Haiyan Tian, Haiyan Tian, Chenming Zhang, Chenming Zhang, Liaoyun Zhang   +12 more
doaj   +2 more sources

Glycosylation of ceramide synthase 6 is required for its activity [PDF]

Journal of Lipid Research
Sphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis.
Alexandra J. Straus, Grace Mavodza, Can E. Senkal   +2 more
doaj   +2 more sources

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution

Biomolecules, 2018
Ceramide synthase 6 (CerS6, also known as LASS6) is one of the six members of ceramide synthase gene family in humans. Comparisons of CerS6 amino acid sequences and structures as well as of CerS6 gene structures/locations were conducted using data from ...
Roger S. Holmes, Keri A. Barron, Natalia I. Krupenko   +2 more
doaj   +2 more sources

Oral Administration of Crocus sativus Tepals Extract Restores High-Fat Diet-Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid Metabolism. [PDF]

Biofactors
This study shows that oral administration of Crocus sativus tepals extract (CTE) restores gut microbiota composition and promotes SCFA‐producing and anti‐inflammatory bacterial genera. It improves intestinal barrier integrity and reduces inflammation in the jejunum and liver, suggesting a possible link between the gut microbiota and the metabolic ...
Bursać B, Vratarić M, Gligorovska L, Bellachioma L, Teofilović A, Vojnović Milutinović D, Morresi C, Damiani E, Bacchetti T, Djordjevic A.   +9 more
europepmc   +2 more sources

Apolipoprotein B48 Knockout Ameliorates High-Fat-Diet-Induced Metabolic Impairment in Mice [PDF]

Biomolecules
This study aimed to investigate whether knockout of the ApoB48 gene improves lipid metabolism disorders induced by a high-fat diet (HFD) in mice. Clustered regularly interspaced short palindromic repeats–Cas9 gene editing technology was used to knock out
Yale Tang, Chao Wang, Luxuan Li, Xiaoyu Wang, Linquan Yang, Xing Wang, Luping Ren, Guangyao Song   +7 more
doaj   +2 more sources

lncRNA CERS6-AS1 upregulates the expression of ANLN by sponging miR-424-5p to promote the progression and drug resistance of lung adenocarcinoma

Non-coding RNA Research
Long non-coding RNAs (lncRNAs) play a crucial role in tumor generation and progression. However, the exact functional significance and underlying molecular mechanism by which lncRNA CERS6-AS1 operates in the context of lung adenocarcinoma (LUAD) remain ...
Shouming Qin, Yanbin Wu
exaly   +3 more sources

Sphingolipids in human disease: organ-specific pathologies, chain-length-dependent effects, and translational implications [PDF]

Journal of Translational Medicine
Background Sphingolipids, particularly ceramide (Cer) and sphingomyelin (SM), are critical for cellular homeostasis, serving as both essential membrane components and key signaling molecules.
Lili Kong, Jiaxin Shi, Siyuan Wang, Jiaqi Huang, Yidong Ge, Yvxuan Li, KaiLang Li, Mengxiang Zhao, Zhiyou Li, Xiaofeng Jin   +9 more
doaj   +2 more sources

Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression [PDF]

Cell & Bioscience
Background & aims Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses various conditions, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis.
Jing Zeng, Grayson Way, Nan Wu, Xixian Jiang, Yun-ling Tai, Derrick Zhao, Lianyong Su, Qianhua Yan, Xuan Wang, Emily C. Gurley, Phillip B. Hylemon, Sayed Obaidullah Aseem, Arun J. Sanyal, Jiangao Fan, Huiping Zhou   +14 more
doaj   +2 more sources

Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carcinoma [PDF]

Scientific Reports
Biological processes intricately intertwine with tumorigenesis, significantly influencing treatment outcomes and prognosis. However, the mechanisms fostering mucoepidermoid carcinoma (MEC) remain inadequately elucidated. This research utilizes expression
Yan-ping Zou, Xiao-feng Shan, Jia-xuan Qiu, Yan Geng, Shang Xie, Ruo-lan Xiang, Zhi-gang Cai   +6 more
doaj   +2 more sources

CERS6 required for cell migration and metastasis in lung cancer [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractSphingolipids constitute a class of bio‐reactive molecules that transmit signals and exhibit a variety of physical properties in various cell types, though their functions in cancer pathogenesis have yet to be elucidated. Analyses of gene expression profiles of clinical specimens and a panel of cell lines revealed that the ceramide synthase ...
Motoshi Suzuki, Ke Cao, Seiichi Kato, Naoki Mizutani, Kouji Tanaka, Chinatsu Arima, Mei Chee Tai, Norie Nakatani, Kiyoshi Yanagisawa, Toshiyuki Takeuchi, Hanxiao Shi, Yasuyoshi Mizutani, Atsuko Niimi, Tetsuo Taniguchi, Takayuki Fukui, Kohei Yokoi, Keiko Wakahara, Yoshinori Hasegawa, Yukiko Mizutani, Soichiro Iwaki, Satoshi Fujii, Akira Satou, Keiko Tamiya‐Koizumi, Takashi Murate, Mamoru Kyogashima, Shuta Tomida, Takashi Takahashi   +26 more
openaire   +2 more sources