Results 1 to 10 of about 1,781 (177)
CerS6 links ceramide metabolism to innate immune responses in diabetic kidney disease [PDF]
Nature CommunicationsEctopic lipid deposition, mitochondrial injury, and inflammatory responses contribute to the development of diabetic kidney disease (DKD); however, the mechanistic link between these processes remains unclear.
Guohua Ding, Zijing Zhu, Zhaowei Chen
exaly +5 more sources
Cancer Medicine, 2020 Breast cancer (BC) leads to the highest mortality in women worldwide, characterized by inevitable proliferation and metastasis of BC cells. Mounting evidence confirm that lncRNAs play a significant role in the tumorigenesis and development of BC.
Gang Bao
exaly +4 more sources
Molecular Metabolism, 2023 Objective: Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality worldwide. Current strategies to manage ALD focus largely on advanced stage disease, however, metabolic changes such as glucose intolerance are apparent at ...
Sookyoung Jeon
exaly +4 more sources
The p53–CerS6 interaction on the ER integrates p53 and sphingolipid signaling pathways in metabolic stress response [PDF]
Journal of Lipid ResearchCeramides, a diverse class of bioactive sphingolipids, play a pivotal role in cellular stress response. We have previously reported a novel mechanism by which a particular member of this class, C16-ceramide, activates death pathways in cancer cells.
Madeline S. Childress +4 more
doaj +3 more sources
LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer [PDF]
Cell Death and Disease, 2021 LncRNAs play essential regulatory roles in pancreatic cancer (PC) tumorigenesis and progression. We aimed to investigate the role of lncRNA CERS6-AS1 in PC. CERS6-AS1 expression was determined in PC tissues and cell lines by PCR analysis.
Jianxin Jiang, Xueyi Jiang, Yankun Chen
exaly +4 more sources
Kaohsiung Journal of Medical Sciences, 2022 Pancreatic cancer (PC) is a lethal malignancy that threatens human health. Long noncoding RNAs (lncRNAs) act as important mediators in PC development. Our study aimed to investigate the function and mechanism of lncRNA ceramide synthase 6 antisense RNA 1
Jiandong Zhang
exaly +2 more sources
Kaohsiung Journal of Medical Sciences, 2022 Accumulating evidence indicates that long noncoding RNAs (lncRNAs) act as tumor promoters or suppressors in various types of cancer. Previous investigations suggest that ceramide synthase 6 (CERS6) antisense RNA 1 (CERS6‐AS1) acts as an oncogene in ...
Xiangbai Wu, Dong-Dong Wang
exaly +2 more sources
CerS6 orchestrates mitochondrial–immune crosstalk via BNIP3-dependent mitophagy suppression and mtDNA–STING/NLRP3 activation in acute lung injury [PDF]
Cellular and Molecular Life SciencesAcute lung injury (ALI) is characterized by impaired alveolar epithelial barrier function and mitochondrial dysfunction in type II alveolar epithelial cells (AT2 cells). Ceramide synthase 6 (CerS6), a key enzyme in sphingolipid metabolism responsible for
Guoqing Luo +10 more
doaj +2 more sources
Determinants of C16-Ceramide Binding to p53 [PDF]
BiomoleculesThe tumor suppressor p53 coordinates cellular stress responses, but underlying mechanisms remain incompletely understood. We previously demonstrated that, in response to metabolic stress, C16-ceramide produced by ceramide synthase 6 (CerS6) directly ...
Madeline S. Childress +3 more
doaj +2 more sources
Localization of Ceramide Synthase 5 in Mouse Retina. [PDF]
J Comp NeurolCerS5 localizes to amacrine cells, horizontal cells, and retinal ganglion cells in the mouse retina. Its deficiency reduces C16‐ceramide and causes retinal thinning without functional ERG deficits, suggesting a structural role for CerS5 in retinal integrity. .
Song SJ +6 more
europepmc +2 more sources