Molecular Metabolism, 2019 Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the ...
Bing Wang +2 more
exaly +8 more sources
Exploring the hub gene CERS6 as a therapeutic target in type 1 diabetes through a bioinformatics and network analyst approach [PDF]
Scientific ReportsInsulin-producing β-cells are destroyed in type 1 diabetes mellitus (T1DM), a chronic autoimmune disease that results in complete insulin insufficiency and metabolic dysfunction.
Hassan Ayaz +7 more
doaj +5 more sources
Effect and Mechanism of lncRNA CERS6-AS1 on the Biological Behavior of Prostate Cancer Cell
Applied Bionics and Biomechanics, 2022 Objective. To investigate the effect of long noncoding RNA (lncRNA) CERS6 antisense RNA1 (CERS6-AS1) on the biological behavior of prostate cancer cells DU145 and its mechanism. Methods.
Fu Huang, Li Quan Zhou
doaj +4 more sources
CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1 [PDF]
Cell Death DiscoveryEsophageal squamous cell carcinoma (ESCC) is associated with poor prognosis because it is typically diagnosed at a moderate or advanced stage. Investigating the precise molecular mechanism of ESCC pathogenesis is essential for developing new therapeutic ...
Wenjing Chen +15 more
doaj +4 more sources
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice [PDF]
Nature Communications, 2023 Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure.
Philipp Hammerschmidt +19 more
doaj +7 more sources
Lipids in Health and DiseaseBackground Stress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can induce mitochondrial damage in hepatocytes, yet the underlying mechanism remains unclear. Ceramide synthase 6
Yichang Liu +11 more
doaj +4 more sources
Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner [PDF]
Frontiers in Nutrition, 2021 Folic acid, an oxidized synthetic pro-vitamin B9, is widely used in vitamin supplement formulations and food fortification to maintain optimal folate status in humans. Studies on folic acid (FA) efficiency in improving folate status and correcting folate
Keri Barron +3 more
doaj +3 more sources
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. [PDF]
PLoS ONE, 2016 We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of several
Baharan Fekry +3 more
doaj +3 more sources
E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression [PDF]
EMBO ReportsBrown adipose tissue (BAT) counteracts obesity-related metabolic dysfunction through both thermogenic and non-thermogenic means. However, substantial evidence indicates that obesity negatively affects BAT mitochondrial morphology and oxidative capacity ...
Fernando Valdivieso-Rivera +16 more
doaj +2 more sources
Association of Clinical Severity in Autism Spectrum Disorder with Biomolecules Involved in Lipid Metabolism, Inflammation and miRNAs [PDF]
BiomoleculesAutism spectrum disorder (ASD) is a heterogeneous neurological condition with an unclear etiology and pathogenesis. In recent years, studies have identified changes in lipid metabolism, inflammation, mitochondrial dysfunction, and mitophagy in patients ...
Maria Gevezova +10 more
doaj +2 more sources