Results 31 to 40 of about 1,781 (177)

Retracted: Effect and Mechanism of lncRNA CERS6-AS1 on the Biological Behavior of Prostate Cancer Cell

Applied Bionics and Biomechanics, 2023
Applied Bionics and Biomechanics
doaj   +2 more sources

Role and mechanism of the CBX4-HDAC5-CERS6 axis in disrupting sphingomyelin metabolism in acute myeloid leukemia. [PDF]

Am J Cancer Res
To investigate the mechanism by which the CBX4-HDAC5-CERS6 axis regulates sphingolipid metabolism in acute myeloid leukemia (AML), with the goal of providing new theoretical foundations for the targeted therapy of AML.This prospective study involved 50 AML patients and 50 healthy controls.
Ye R, Sun M, Huang J, Sun L, Wu Y, Zou X, Tang H.   +6 more
europepmc   +4 more sources

Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway

Cell Death Discovery, 2022
Hepatocellular carcinoma (HCC) is one of the most serious malignant cancers and has a high fatality rate. However, clinical strategies for the effective treatment of HCC remain lacking.
Bo Xu, Yonggang Wei, Fei Liu, Lian Li, Siqi Zhou, Yufu Peng, Bo Li   +6 more
doaj   +1 more source

Long non-coding RNA CERS6-AS1 plays a prognostic role in promoting the progression of gastric cancer [PDF]

Bioengineered, 2021
This study aims to investigate the potential clinical function of long non-coding RNA CERS6-AS1 (lncRNA CERS6-AS1) integrated miR-567 in gastric cancer. The expression of CERS6-AS1 in gastric cancer tissues was detected through RT-qPCR in contrast to the normal tissues.
Zhengliang Li, Xiaojing Liu, Nan Luo, Yali Pang, Yubin Hou, Guoxiang Jiang   +5 more
openaire   +2 more sources

Generation of CerS6^ADAAAIA mice.

, 2022
The CerS6 genomic region showing the CRISPR/Cas9 design for editing the CerS6 DDRSDIE motif. Genomic location (mm10 chr2:68,861,441–69,114,282) of the guide RNA cleavage site is shown as a dashed line.
Tammar Joseph (13113473), Shifra Ben-Dor (539029), Anthony H. Futerman (440004), Jiyoon Kim (758075), Yael Pewzner-Jung (587457)   +4 more
core   +1 more source

CERS6 promotes ESCC cell proliferation by increasing the stability of RPN1

, 2023
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis because it is typically diagnosed at a moderate or advanced stage. Investigating the precise molecular mechanism of ESCC pathogenesis is essential for developing new therapeutic strategies ...
Kangdong Liu (14143195), Yanan Jiang (16832245), Yuhan Zhang (2792089), Yuxin Zhai (2499973), Junyong Wang (3807964), Dan Gao (410390), Qiong Wu (84327), Jimin Zhao (482148), Weizhe Zhang (286664), Zhiying Zhao (188792), Xiaoxiao Yang (3800128), Xiaokun Zhao (212561), Nannan Zhao (4331221), Zigang Dong (180050), Wenjing Chen (383602), Qiang Yuan (240079)   +15 more
core   +1 more source

The Role of Bone Morphogenetic Protein 9 in Nonalcoholic Fatty Liver Disease in Mice

Frontiers in Pharmacology, 2021
Background and Aims: It’s reported that bone morphogenetic protein 9 (BMP9) played an important role in lipid and glucose metabolism, but the role of BMP9 in nonalcoholic fatty liver disease (NAFLD) is unclear. Here, we evaluated the therapeutic efficacy
Qin-Juan Sun, Ling-Yan Cai, Jie Jian, Ya-Lu Cui, Chen-Kai Huang, Shu-Qing Liu, Jin-Lai Lu, Wei Wang, Xin Zeng, Lan Zhong   +9 more
doaj   +1 more source

LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2 [PDF]

, 2023
Cervical cancer (CC) is a common disease in women characterized by high recurrence rate. LncRNA ceramide synthase 6 antisense RNA 1 (CERS6-AS1) has been found to play a crucial role in the progression of breast cancer and pancreatic cancer ...
Chu, Guanghua, Liu, Chen, Ma, Shuyun, Li, Long, Wang, Xinru, Hu, Chunyan, Yan, Kun   +6 more
core  

Involvement of ceramide biosynthesis in increased extracellular vesicle release in Pkd1 knock out cells

Frontiers in Endocrinology, 2022
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited disorder characterized by the development of renal cysts, which frequently leads to renal failure.
Valentina Carotti, Jenny van der Wijst, Eric H. J. Verschuren, Luco Rutten, Nico Sommerdijk, Charlotte Kaffa, Vera Sommers, Juan P. Rigalli, Joost G. J. Hoenderop   +8 more
doaj   +1 more source

CerS6 gene methylation in peripheral blood is associated with asthma and the frequent exacerbator phenotype

, 2023
Background Sphingolipids metabolism regulated by ceramide synthase (CerS) enzyme is closely related to asthma development, but the underlying biological mechanism remains unclear. Since epigenetics plays a critical role in the pathogenesis of asthma, we thus studied the DNA methylation of CerS1-6
Zhu Song, Yuting Wang, Heqing Huang, Tingting Hu, Xu Gao, Chun Chang   +5 more
openaire   +1 more source