Results 71 to 80 of about 1,781 (177)

Methotrexate induces CerS6-dependent formation of ER membrane aggregates in A549 non-small cell lung carcinoma cells.

, 2016
(A) Treatment with MTX (10 nM) resulted in the increase of autophagosome number, but CerS6 was not associated with these organelles. (B) MTX (10 nM) induced aggregation of ER membranes and the accumulation of CerS6 in the aggregates.
Natalia I. Krupenko (439696), Amin Esmaeilniakooshkghazi (846617), Baharan Fekry (846616), Sergey A. Krupenko (439695)   +3 more
core   +1 more source

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

, 2022
S.825-836Ceramides are mediators of inflammatory processes. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we observed that CerS6 mRNA expression was upregulated 15-fold in peripheral blood leukocytes ...
Willecke, K., Foerch, C., Tafferner, N., Ulshöfer, T., Ebel, P., Barthelmes, J., Ferreiros, N., Männer de Bazo, A., Geisslinger, G., Eberle, M., Schiffmann, S., Mayer, C.A., Henke, M., Grösch, S.   +13 more
core   +1 more source

Periplocymarin Alleviates Doxorubicin-Induced Heart Failure and Excessive Accumulation of Ceramides

Frontiers in Cardiovascular Medicine, 2021
Doxorubicin-driven cardiotoxicity could result in dilated cardiomyopathy and heart failure (HF). Previously, we showed that periplocymarin exerted a cardiotonic role by promoting calcium influx and attenuating myocardial fibrosis induced by isoproterenol
Weijing Yun, Lei Qian, Ruqiang Yuan, Hu Xu   +3 more
doaj   +1 more source

From correlation to causation: cell‐type‐specific gene regulatory networks in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves complex regulatory disruptions across multiple brain cell types, yet the comprehensive intracellular causal mechanisms remain poorly understood. METHODS We present an integrative analysis framework using single‐nucleus transcriptomics with matched subject‐level genotype data from 272 AD patients ...
Danni Liu, Zhongli Jiang, Hyunjin Kim, Anke M. Tukker, Ashish Dalvi, Junkai Xie, Yan Li, Chongli Yuan, Aaron B. Bowman, Dabao Zhang, Min Zhang   +10 more
wiley   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, Volume 108, Issue 2, Page 676-693, February 2026.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson's Disease Locus. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) in Parkinson's disease (PD) have identified over 20 genomic regions associated with disease risk. Many of these loci include several candidate genes making it difficult to pinpoint the causal gene.
Catherine Labbé, Kotaro Ogaki, Oswaldo Lorenzo-Betancor, Minerva M Carrasquillo, Michael G Heckman, Allan McCarthy, Alexandra I Soto-Ortolaza, Ronald L Walton, Timothy Lynch, Joanna Siuda, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Krzysztof Czyzewski, Dennis W Dickson, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross   +17 more
doaj   +1 more source

Sphingolipids in Emotional Well‐Being

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Sphingolipids are essential constituents of neuronal membranes and are increasingly recognized as contributors to the key behavioral manifestations associated with emotional well‐being. ABSTRACT Emotional well‐being is a multifactorial concept, which comprises not only life quality of human individuals, but also their mental and physical health.
L. S. Kalinichenko, I. Zoicas, C. Mühle, J. Kornhuber, C. P. Müller   +4 more
wiley   +1 more source

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao, Xudong Feng, Qigu Yao, Weiqin Ji, Xinying Zhang, Qiaoling Pan, Bin Zhu, Jiong Yu, Hongcui Cao, Xianfeng Zhang   +9 more
wiley   +1 more source

C16-ceramide and sphingosine 1-phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation

, 2021
Recently, sphingolipid derivatives, such as ceramide and sphingosine-1-phosphate (S1P), have emerged as key modulators in apoptotic cell death and cell proliferation.
박주원, 김민혜, 안정혁
core   +1 more source

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6 [PDF]

, 2015
Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic
Kashkar, H, Seeger, JM, Wiesner, RJ, Andree, M, Schüll, S, Brodesser, S, Wiegmann, K, Tosetti, B, Pongratz, C, Krönke, M, Diaz, F, Witt, A, Günther, SD, Brinkmann, K   +13 more
core   +2 more sources