Results 161 to 170 of about 6,033 (189)

Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway. [PDF]

Cell Death Dis
Feng C, Mao W, Yuan C, Dong P, Liu Y.
europepmc   +1 more source

Genetic Evidence Reveals Causal Effect of Circulating Proteome on Random Glucose: A Mendelian Randomization Study. [PDF]

J Diabetes Res
Shen Z, Xing X, Zhang X, Zhu J, Wang Y, Cai G.   +5 more
europepmc   +1 more source

Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis. [PDF]

Autophagy
Choi YJ, Nam YA, Hyun JY, Yu J, Mun Y, Yun SH, Lee W, Park CJ, Han BW, Lee BH.   +9 more
europepmc   +1 more source

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran. [PDF]

Front Pharmacol
Yang Z, Tan WR, Li Q, Wang Y, Liu S, Chen L, Zhou Y, Zeng C, Zeng Y, Xiong Y, Zhang Q, Li N, Du P, Liu L, Chen J, He Y.   +15 more
europepmc   +1 more source

Regulation of Human Hydrolases and Its Implications in Pharmacokinetics and Pharmacodynamics. [PDF]

Drug Metab Dispos
Jung SM, Zhu HJ.
europepmc   +1 more source

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans. [PDF]

Front Pharmacol
Park JW, Kim JM, Bang YY, Kim KA, Yu S, Park JY.   +5 more
europepmc   +1 more source

A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications. [PDF]

NPJ Genom Med
Shorbaji A, Pushparaj PN, Al-Ghafari AB, Mira LS, Basabrain MA, Naseer MI, Ahmed F, Abu-Elmagd M, Rasool M, Bakhashab S.   +9 more
europepmc   +1 more source

Abstract 2073 KNOCKDOWN OF CES1 IN THP-1 MACROPHAGES PROMOTES A PROINFLAMMATORY PHENOTYPE

Journal of Biological Chemistry
Oluwabori Adekanye, Abdolsamad Borazjani, Matthew Ross   +2 more
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Natural Products as Modulators of CES1 Activity

Drug Metabolism and Disposition, 2020
Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 ...
Yuli Qian, John S. Markowitz
openaire   +2 more sources