Results 181 to 189 of about 6,033 (189)

Carboxylesterase 1 (Ces1) Releases Oxylipins From Oxidized Triacylglycerols: Examination of Its Substrate Selectivity

The FASEB Journal, 2022
Triacylglycerols (TAGs) are the most quantitatively important storage form of fat and are found primarily in cytoplasmic lipid droplets within cells. TAGs are broken down to its component free fatty acids by lipolytic enzymes when fuel reserves are required. However, when TAGs possess large quantities of polyunsaturated fatty acids
Matthew K. Ross, Maggie Phillips, Abdolsamad Borazjani   +2 more
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Pyrazolone compounds could inhibit CES1 and ameliorates fat accumulation during adipocyte differentiation

Bioorganic Chemistry
Carboxylesterase 1 (CES1), a member of the serine hydrolase superfamily, is involved in a wide range of xenobiotic and endogenous substances metabolic reactions in mammals. The inhibition of CES1 could not only alter the metabolism and disposition of related drugs, but also be benefit for treatment of metabolic disorders, such as obesity and fatty ...
Dan-Dan Wang, Zhen-Zhen Wang, Wen-Cai Liu, Xing-Kai Qian, Ya-Di Zhu, Tie-Gang Wang, Shu-Mei Pan, Li-Wei Zou   +7 more
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Abstract 3620: Tumor targeted delivery of glutamine antagonist: Use of CES1-/- mice

Cancer Research, 2019
Abstract 6-diazo-5-oxo-L-norleucine (DON), a potent glutamine antagonist, broadly blocks glutamine utilizing reactions critical for the synthesis of nucleic acids, amino acids, proteins and the generation of alpha-ketoglutarate for energy metabolism.
Rana Rais, Jesse Alt, Ranjeet Dash, Lukáš Tenora, Pavel Majer, Barbara S. Slusher   +5 more
openaire   +1 more source

The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans

European Journal of Clinical Pharmacology, 2012
The aim of this study was to examine whether carboxylesterase 1 (CES1A) genetic polymorphisms affect the pharmacokinetics of oseltamivir.Thirty healthy Japanese male and female subjects ranging in age from 20 to 36 years voluntarily participated in this study.
Yuki, Suzaki, Naoto, Uemura, Makoto, Takada, Tetsuji, Ohyama, Akiko, Itohda, Takuya, Morimoto, Hiromitsu, Imai, Hajime, Hamasaki, Akihiro, Inano, Masakiyo, Hosokawa, Masato, Tateishi, Kyoichi, Ohashi   +11 more
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The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect

Drug Metabolism and Drug Interactions, 2014
Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Several common genetic variants of the CES1 and CES2 genes have been shown to influence drug metabolism and clinical outcomes. Polymorphisms of
Zahra, Merali, Stephanie, Ross, Guillaume, Paré   +2 more
openaire   +2 more sources

P186 - pH dependent CES1 mediated hydrolysis of vixotrigine in human liver microsomes

Drug Metabolism and Pharmacokinetics, 2020
Joshua Johnson, Michael Rooney, Chungang Gu   +2 more
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A Comprehensive Functional Assessment of CES1 Nonsynonymous Variants

The FASEB Journal, 2017
Xinwen Wang, Nada Rida, Jian Shi, Hao‐Jie Zhu   +3 more
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CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary microvascular loss and obliterative remodeling, driven by metabolic reprogramming, oxidative stress, and endothelial dysfunction. While BMPR2 mutations contribute to metabolic shifts in pulmonary microvascular endothelial cells (PMVECs), their low ...
Stuti Agarwal, Lyong Heo, Ananya Chakraborty, Ankita Mitra, Lichao Liu, Natasha Auer, Gowri Swaminathan, Flora Huang, Prakash Chelladurai, Eleana Guardado, Juan Matos, Anuradha Bankar, Crystal Le, James West, Karthik Suresh, Ramesh V Nair, Marlene Rabinovitch, Bruce D. Hammock, Christophe Morisseau, Joseph C Wu, Zoltan Arany, Mark R. Nicolls, Vinicio A. de Jesus Perez   +22 more
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CES1 Deficiency Is Associated With Endothelial Dysfunction and Metabolic Reprograming in PAH

B95. SURFING IN THE GREEN ROOM: DEFINING MOLECULAR MECHANISMS OF PULMONARY VASCULAR DISEASE
S. Agarwal, L. Heo, A. Chakraborty, J.D. West, K. Suresh, R.V. Nair, M.R. Nicolls, C. Morisseau, B.D. Hammock, R.A. Lafyatis, S.M. Kawut, R.T. Zamanian, V. De Jesus Perez   +12 more
openaire   +1 more source