Results 1 to 10 of about 34,737 (190)
Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cell Reports, 2023 Summary: Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for a healthy immune system.
Heng Lyu +6 more
doaj
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Nature Reviews Nephrology, 2022 Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other cytokines that activate immune cells and ...
Sladjana Skopelja-Gardner +2 more
semanticscholar +1 more source
cGAS Dimerization Entangles DNA Recognition [PDF]
Immunity, 2013 Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.
Philip J. Kranzusch, Russell E. Vance
openaire +3 more sources
Drug Design, Development and Therapy, 2020 Yixing Tian, Zhaohua Bao, Yiming Ji, Xin Mei, Huilin Yang Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Huilin Yang Email suzhouspine@163 ...
Tian Y, Bao Z, Ji Y, Mei X, Yang H
doaj
Tight nuclear tethering of cGAS is essential for preventing autoreactivity
eLife, 2019 cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.
Hannah E Volkman +3 more
doaj +1 more source
Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]
, 2010 This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...
core
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
Cell Research, 2020 CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to ...
Mengze Lv +15 more
semanticscholar +1 more source
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses
Nature Communications, 2022 cGAS-STING pathway is a key DNA-sensing machinery and emerges as a promising target to overcome the immunoresistance of solid tumors. Here we describe a bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions and β ...
Xuan Wang +7 more
semanticscholar +1 more source