Results 1 to 10 of about 41,079 (213)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability [PDF]

Cells, 2019
Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation.
Christy Hong, Andrea E. Tijhuis, Floris Foijer   +2 more
doaj   +3 more sources

Cytosolic DNA sensing by cGAS: regulation, function, and human diseases

Signal Transduction and Targeted Therapy, 2021
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary
Pengda Liu
exaly   +2 more sources

Distinct Domains Contribute to the Subcellular Localization of Human cGAS in Yeast [PDF]

Biomolecules
Cyclic GMP-AMP synthase (cGAS) functions as a DNA sensor in the cytoplasm, triggering immune responses, but it is also translocated to the nucleus, where it is kept catalytically inactive.
Sara López-Montesino, Julia María Coronas-Serna, Humberto Martín, María Molina, Víctor J. Cid   +4 more
doaj   +2 more sources

SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction

Viruses, 2020
Several DNA viruses have evolved antagonists to inhibit the cyclic GMP−AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA-sensing immune pathway.
Joshua B. Reus, Guillermo S. Trivino-Soto, Lily I. Wu, Kristiana Kokott, Efrem S. Lim   +4 more
doaj   +1 more source

cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages

Gut Microbes, 2021
Although cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling has been well recognized in defending DNA viruses, the role of cGAS-STING signaling in regulating infection of RNA viruses remains largely elusive.
Peifa Yu, Zhijiang Miao, Yang Li, Ruchi Bansal, Maikel P. Peppelenbosch, Qiuwei Pan   +5 more
doaj   +1 more source

Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS

Cell Reports, 2023
Summary: Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for a healthy immune system.
Heng Lyu, Le Sun, Zhenyu Guan, Jinxin Li, Changsong Yin, Yaoyang Zhang, Hong Jiang   +6 more
doaj   +1 more source

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications

OncoImmunology, 2020
Resiquimod (R848) and motolimod (VTX-2337) are second-generation experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory properties originally approved by the US Food and Drug Administration for the topical treatment of actinic ...
Giorgio Frega, Qi Wu, Julie Le Naour, Erika Vacchelli, Lorenzo Galluzzi, Guido Kroemer, Oliver Kepp   +6 more
doaj   +1 more source

Evaluation of early and very early onset schizophrenic disorder cases in a child and adolescent psychiatric inpatient unit

Journal of Behçet Uz Children's Hospital, 2019
INTRODUCTION: Early-onset and very early-onset schizophrenia is a chronic disorder characterized by symptoms of thought, perception, emotion, movement, and behavior that started before the age of 18.
Burcu Serim Demirgören
doaj   +1 more source

cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

Frontiers in Immunology, 2022
IntroductionType I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production.
Sarinya Kumpunya, Arthid Thim-uam, Chisanu Thumarat, Asada Leelahavanichkul, Nuttiya Kalpongnukul, Nuttiya Kalpongnukul, Naphat Chantaravisoot, Naphat Chantaravisoot, Trairak Pisitkun, Trairak Pisitkun, Prapaporn Pisitkun, Prapaporn Pisitkun   +11 more
doaj   +1 more source

Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy

Frontiers in Immunology, 2022
The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases.
Min Zhang, Min Zhang, Yan Zou, Yan Zou, Xujun Zhou, Xujun Zhou, Jinming Zhou, Jinming Zhou   +7 more
doaj   +1 more source