Results 11 to 20 of about 34,737 (190)
The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability [PDF]
Cells, 2019 Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation.
Christy Hong +2 more
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cGAS–STING, an important signaling pathway in diseases and their therapy
MedCommSince cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS–
Qijie Li +5 more
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Agonists and Inhibitors of the cGAS-STING Pathway
MoleculesThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agonists
Xiaoxuan Yu +4 more
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Nuclear cGAS: sequestration and beyond [PDF]
Protein & Cell, 2021 AbstractThe cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it ...
Feng Liu, Feng Liu, Juli Bai, Juli Bai
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
Nature reviews. Immunology, 2021 The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the ...
Alexiane Decout +3 more
semanticscholar +1 more source
cGAS–STING drives ageing-related inflammation and neurodegeneration
Nature, 2023 The cGAS–STING signalling pathway is a critical driver of chronic inflammation and functional decline during ageing, and could be targeted to halt neurodegenerative processes during old age.
M. F. Gulen +12 more
semanticscholar +1 more source
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine, 2023 Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeongha Kim, Ho-Shik Kim, Jay H. Chung
semanticscholar +1 more source
Virologica Sinica, 2018 The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage ...
Meiguang Xiong +3 more
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The multifaceted functions of cGAS
Journal of Molecular Cell Biology, 2022 Abstract Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a ...
Liu, Haipeng +4 more
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Nuclear cGAS: guard or prisoner? [PDF]
The EMBO Journal, 2021 cGAS, an innate immune sensor of cellular stress, recognizes double-stranded DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or malignancy. Early models suggested that cytosolic localization of cGAS prevents autoreactivity to nuclear and mitochondrial self-DNA, but this paradigm has shifted in light of recent findings ...
Carina C de Oliveira Mann +1 more
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