Results 11 to 20 of about 31,976 (243)
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]
, 2019 Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister +77 more
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Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]
, 2017 Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre +13 more
core +3 more sources
cGAS is essential for cellular senescence [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown.
Hui Yang +4 more
openaire +3 more sources
The role of cGAS/STING in intestinal immunity [PDF]
European Journal of Immunology, 2021 AbstractThe gastrointestinal tract is a highly complex microenvironment under constant interaction with potentially harmful pathogens. Inflammatory bowel disease (IBD) is an archetypical inflammatory disease, in which the intestinal epithelium, defective autophagy, endoplasmic reticulum stress and dysbiosis play a key role.Although no risk‐mediating ...
Felix Wottawa +4 more
openaire +3 more sources
Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
core +1 more source
Pharmacological Activation of cGAS for Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2021 When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer. Specifically, the accumulation of double-stranded DNA in the cytosol can efficiently promote antitumor immunity by activating the cGAMP synthase (cGAS) / stimulator of interferon genes ...
Kyle M. Garland +15 more
openaire +4 more sources
Using stepped-care approaches within internet-based interventions for youth anxiety: Three case studies. [PDF]
, 2019 Background There are a lack of clear guidelines for the dissemination of Internet-based cognitive behaviour therapy (ICBT) for childhood and adolescent anxiety in routine care.
Baldwin, Sarah +4 more
core +2 more sources
Clumping factors of HII, HeII and HeIII
, 2014 Estimating the intergalactic medium ionization level of a region needs proper treatment of the reionization process for a large representative volume of the universe.
Ciardi, Benedetta +2 more
core +1 more source
An API for IPv6 Multihoming [PDF]
, 2006 IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6?8 July, 2005This paper proposes an API for Multihoming in IPv6. This API is based on the Hash Based Addresses and Cryptographically Generated Addresses approaches, which ...
Bagnulo Braun, Marcelo Gabriel +2 more
core +2 more sources
, 2020 Multitasking optimization is a recently introduced paradigm, focused on the simultaneous solving of multiple optimization problem instances (tasks). The goal of multitasking environments is to dynamically exploit existing complementarities and synergies ...
Del Ser, Javier +4 more
core +1 more source