Results 11 to 20 of about 41,079 (213)
Microbiology SpectrumCyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang +9 more
doaj +3 more sources
Nuclear cGAS: sequestration and beyond [PDF]
Protein & Cell, 2021 AbstractThe cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it ...
Juli Bai, Feng Liu
openaire +2 more sources
UHPLC-PDA-ESI-TOF/MS metabolic profiling and antioxidant capacity of arabica and robusta coffee silverskin: antioxidants vs phytotoxins [PDF]
, 2017 A deeper knowledge of the chemical composition of coffee silverskin (CS) is needed due to the growing interest in its use as a food additive or an ingredient of dietary supplements.
Lavecchia, R. +3 more
core +1 more source
Virologica Sinica, 2018 The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage ...
Meiguang Xiong +3 more
openaire +2 more sources
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
core +2 more sources
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]
The Journal of Immunology, 2017 Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao +8 more
openaire +2 more sources
Autonomous virulence adaptation improves coevolutionary optimization [PDF]
, 2011 A novel approach for the autonomous virulence adaptation (AVA) of competing populations in a coevolutionary optimization framework is presented.
Ait-Boudaoud, D, Cartlidge, J
core +2 more sources
Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
core +1 more source
Trial watch: STING agonists in cancer therapy
OncoImmunology, 2020 Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour +4 more
doaj +1 more source
cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness
Translational Oncology, 2022 The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu +4 more
doaj +1 more source