Results 71 to 80 of about 31,976 (243)

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]

, 2019
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju, Dobbs, Nicole, Liou, Jen, Miner, Jonathan J, Sakai, Tomomi, Wu, Jianjun, Yan, Nan   +6 more
core   +1 more source

Planetary Growth with Collisional Fragmentation and Gas Drag [PDF]

, 2010
As planetary embryos grow, gravitational stirring of planetesimals by embryos strongly enhances random velocities of planetesimals and makes collisions between planetesimals destructive.
Adachi, Alexander V. Krivov, Benz, Blum, Bodenheimer, Brauer, Bromley, Chambers, Crida, Cuzzi, Desch, Gomes, Hayashi, Hidekazu Tanaka, Hiroshi Kobayashi, Ikoma, Inaba, Inaba, Inaba, Inaba, Iwasaki, Johansen, Johansen, Kenyon, Kenyon, Kenyon, Kobayashi, Kokubo, Kokubo, Kokubo, Kokubo, Kusaka, Laughlin, Levison, Makino, Mizuno, Morbidelli, Ohtsuki, Pollack, Satoshi Inaba, Stewart, Tanaka, Tanaka, Weidenschilling, Weidenschilling, Wetherill, Wetherill   +46 more
core   +2 more sources

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source

A Multiphase Model for the Intracluster Medium [PDF]

, 1999
Constraints on the clustered mass density \Omega_m of the universe derived from the mean intracluster gas fraction of X-ray clusters may be biased by a single-phase assumption for the thermodynamic structure of the intracluster medium (ICM). We propose a
A. E. Evrard, Birkinshaw M., Cavaliere A., Cen R., Cole S., D. Nagai, David L. P., Eke V. R., Fabian A. C., Frenk C. S., Gunn K. F., Hamuy M., Inagaki Y., Irwin J. A., Irwin J. A., Jones M., M. E. Sulkanen, Mohr J. J., Navarro J. F., Neumann D. M., Nulsen P. E. J., Peres C. B., Raymond J. C., Riess A. G., Thomas P., Thomas P. A., White D. A., White S. D. M., Zaroubi S.   +28 more
core   +3 more sources

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, EarlyView.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang, Zhengren Xu, Wei Wang, Haihua Xiao, Zhiqiang Lin, Hongbin Han   +14 more
wiley   +1 more source

Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? [PDF]

, 2014
The effect of roasting of coffee beans and the extraction of ground coffee with different volumes of hot pressurised water on the caffeine and the total caffeoylquinic acids (CQAs) content of the resultant beverages was investigated.
Alan Crozier, Concepción Cid, Daniele Del Rio, Iziar A. Ludwig, Luca Calani, Michael E. J. Lean, Pedro Mena   +6 more
core   +1 more source

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape [PDF]

, 2015
A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated nucleic acids to initiate crucial innate immune responses in host organisms.
Clark, NL, Elde, NC, Hagan, C, Hancks, DC, Hartley, MK   +4 more
core   +4 more sources