Protein & Cell, 2020 The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading
Mi Li, Hong-Bing Shu
doaj +1 more source
Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
PLOS Pathogens, 2020 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in understanding the roles of canonical RNA sensing pathways in the host recognition of CHIKV; however, less is
L. G. Webb +16 more
openaire +4 more sources
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]
, 2018 The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda +64 more
core +2 more sources
Improving safety of runway overrun through the correct numerical evaluation of rutting in Cleared and Graded Areas [PDF]
, 2014 Aircraft overrun is potentially very dangerous to human life. Statistics show that overrun is mainly due to human errors causing loss of control in wheel alignment, high approach speed, and long touchdown.
Benedetto, Andrea +2 more
core +1 more source
T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function
Cell ReportsSummary: While cGAS is known as a cytosolic DNA sensor in innate immunity, its function in T cells and adaptive immunity remains uncharacterized. This study investigates the role of cGAS in regulatory T (Treg) cells.
Hongpeng Li +3 more
doaj +1 more source
Centrally Extended Conformal Galilei Algebras and Invariant Nonlinear PDEs
, 2015 We construct, for any given $ \ell = \frac{1}{2} + {\mathbb N}_0, $ the second-order \textit{nonlinear} partial differential equations (PDEs) which are invariant under the transformations generated by the centrally extended conformal Galilei algebras ...
Aizawa, Naruhiko, Kato, Tadanori
core +2 more sources
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape [PDF]
, 2015 A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated nucleic acids to initiate crucial innate immune responses in host organisms.
Clark, NL +4 more
core +4 more sources
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
iScience, 2020 Summary: cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. cGAS interactome largely includes mammalian or viral proteins.
Yanqiong Zhang +13 more
doaj +1 more source
Phase Diagrams for Sonoluminescing Bubbles [PDF]
, 1996 Sound driven gas bubbles in water can emit light pulses. This phenomenon is called sonoluminescence (SL). Two different phases of single bubble SL have been proposed: diffusively stable and diffusively unstable SL.
Birkhoff G. +4 more
core +4 more sources
SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]
, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E +10 more
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