Biochemical and Molecular Characterization of the Rice Chalcone Isomerase Family [PDF]
Plants, 2021 Chalcone isomerase (CHI) is a key enzyme in flavonoid biosynthesis. In plants, CHIs occur in multigene families, and they are divided into four types, types I–IV.
Man-Ho Cho, Hye Lin Park, Sangil Park
exaly +7 more sources
Chalcone Isomerase a Key Enzyme for Anthocyanin Biosynthesis in Ophiorrhiza japonica [PDF]
Frontiers in Plant Science, 2019 Anthocyanins are distributed ubiquitously to terrestrial plants and chalcone isomerase (CHI) catalyzes the stereospecific isomerization of chalcones – a committed step in the anthocyanin biosynthesis pathway.
Ming Tang, Yin Yi, Zhigang Ju
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Evolutionary landscape of plant chalcone isomerase-fold gene families [PDF]
Frontiers in Plant ScienceFlavonoids are crucial for plant survival and adaptive evolution, and chalcone isomerase (CHI) genes serve as key rate-limiting gene in the flavonoid biosynthesis pathway.
Kai-yong Luo +13 more
exaly +6 more sources
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity [PDF]
Nature Communications, 2020 Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al.
Toshiyuki Waki +20 more
doaj +5 more sources
Molecular mechanism underlying regulation of chalcone synthase by chalcone isomerase-like protein [PDF]
Nature CommunicationsFlavonoids are essential for plant growth and environmental adaptation. Chalcone synthase (CHS) directs metabolic flux into flavonoid biosynthesis, but its catalytic promiscuity limits the biosynthetic efficiency.
Song Wang +17 more
doaj +4 more sources
AfCHIL, a Type IV Chalcone Isomerase, Enhances the Biosynthesis of Naringenin in Metabolic Engineering [PDF]
Frontiers in Plant Science, 2022 Naringenin is an essential precursor for all flavonoids, and effectively promoting naringenin production is crucial in metabolic engineering. The interaction between plant metabolic enzymes ensures metabolic flux.
Lecheng Liu, Xu Huanhuan, Yanping Lan
exaly +4 more sources
Biocatalytic access to diverse prenylflavonoids by combining a regiospecific C-prenyltransferase and a stereospecific chalcone isomerase [PDF]
Acta Pharmaceutica Sinica B, 2018 Prenylflavonoids are valuable natural products that have diverse biological properties, and are usually generated biologically by multiple metabolic enzymes in nature.
Dawei Chen, Jungui Dai, Ridao Chen
exaly +4 more sources
Overexpression of chalcone isomerase A gene in Astragalus trigonus for stimulating apigenin [PDF]
Scientific Reports, 2021 Apigenin is one of the most studied flavonoids and is widely distributed in the plant kingdom. Apigenin exerts important antioxidant, antibacterial, antifungal, antitumor activities, and anti-inflammatory effects in neurological or cardiovascular disease.
Nagwa I. Elarabi +4 more
doaj +5 more sources
Molecular cloning and functional characterization of chalcone isomerase from Carthamus tinctorius [PDF]
AMB Express, 2019 Flavonoid is one of the widespread groups of plant secondary metabolites that provide several health benefits. However, the explicit mechanism of flavonoid biosynthesis in plants largely remains unclear.
Xiuming Liu +12 more
doaj +5 more sources
Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase. [PDF]
J Nat Prod, 2023 By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization.
Furumura S +7 more
europepmc +3 more sources