Structural Basis for (2R,3R)-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus [PDF]
Molecules, 2022 The bacterial chalcone isomerase (CHI) from Eubacterium ramulus catalyses the first step in a flavanone-degradation pathway by a reverse Michael addition.
Gottfried J. Palm +3 more
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Integrative analysis of transcriptome and metabolome reveals the effect of DNA methylation of chalcone isomerase gene in promoter region on Lithocarpus polystachyus Rehd flavonoids [PDF]
Synthetic and Systems Biotechnology, 2022 Metabolite biosynthesis is regulated by gene expression, which is altered by DNA methylation in the promoter region. Chalcone isomerase (CHI) gene encodes a key enzyme in the Lithocarpus polystachyus Rehd flavonoid pathway, and the expression of L ...
Limei Lin +8 more
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Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein. [PDF]
Int J Mol SciChalcone synthase (CHS) and chalcone isomerase (CHI) catalyze the first two committed steps of the flavonoid pathway that plays a pivotal role in the growth and reproduction of land plants, including UV protection, pigmentation, symbiotic nitrogen fixation, and pathogen resistance.
Lewis JA +7 more
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Identification of chalcone isomerase gene family in Astragalus mongholicus revealed genes regulating isoflavone synthesis [PDF]
Frontiers in Plant ScienceAstragalus mongholicus (AM) is the original plant of the famous traditional Chinese medicine Astragali Radix, and its isoflavones are important bioactive substances with wide-ranging medicinal values.
Zhen Wang +8 more
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Regulatory ligand binding in plant chalcone isomerase-like (CHIL) proteins. [PDF]
J Biol Chem, 2023 Chalcone isomerase-like (CHIL) protein is a noncatalytic protein that enhances flavonoid content in green plants by serving as a metabolite binder and a rectifier of chalcone synthase (CHS). Rectification of CHS catalysis occurs through direct protein-protein interactions between CHIL and CHS, which alter CHS kinetics and product profiles, favoring ...
Wolf-Saxon ER +5 more
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Chalcone isomerase family and fold: No longer unique to plants [PDF]
Protein Science, 2004 Abstract Chalcone isomerase, an enzyme in the isoflavonoid pathway in plants, catalyzes the cyclization of chalcone into ( 2S )‐naringenin. Chalcone isomerase sequence family and three‐dimensional fold appeared to be unique to plants and has been proposed as a plant‐specific
Michael Gensheimer, Arcady Mushegian
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Identification of chalcone isomerase family genes and roles of DnCHI1 in flavonoid metabolism in Dendrobium nobile [PDF]
Frontiers in Plant ScienceDendrobium nobile is a prized orchid species with both medicinal and ornamental values, known for accumulating flavonoids that contribute to its bioactivity and flower pigmentation.
Ling-ling Chang +4 more
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Identification and evolutionary analysis of chalcone isomerase-fold proteins in ferns. [PDF]
J Exp Bot, 2020 The emergence of type I CHIs may have occurred at the time of the divergence of the pteridophytes, with CHIL interacting with both CHS and CHI to promote flavonoid synthesis.
Ni R +7 more
europepmc +3 more sources
Crystal structure and enzymatic properties of chalcone isomerase from the Antarctic vascular plant Deschampsia antarctica Desv. [PDF]
PLoS ONE, 2018 Chalcone isomerase (CHI) is an important enzyme for flavonoid biosynthesis that catalyzes the intramolecular cyclization of chalcones into (S)-flavanones. CHIs have been classified into two types based on their substrate specificity.
Sun-Ha Park +6 more
doaj +2 more sources
Three AP2/ERF family members modulate flavonoid synthesis by regulating type IV chalcone isomerase in citrus [PDF]
Plant Biotechnology Journal, 2021 Changjie Xu, Bo Zhang, Meng Xu
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