Pharmacological potential of natural chalcones: a recent studies and future perspective [PDF]
Frontiers in PharmacologyChalcones isolated from natural sources are the primary metabolites of numerous biologically intriguing and pharmacologically essential drugs. Chalcones’ pharmacological properties are believed to result from a double bond conjugated to carbonyl ...
Suman Adhikari +6 more
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Chalcones and Dihydrochalcones Augment TRAIL-Mediated Apoptosis in Prostate Cancer Cells [PDF]
Molecules, 2010 Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent.
Wojciech Krol +4 more
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Flavonoids, Chalcones, and Their Fluorinated Derivatives—Recent Advances in Synthesis and Potential Medical Applications [PDF]
MoleculesFlavonoids and chalcones, widely recognised for their diverse biological activities, have garnered attention due to their potential therapeutic applications.
Jakub Kubiak +3 more
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Antiviral properties of chalcones and their synthetic derivatives: a mini review [PDF]
Pharmacia, 2020 Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions.
Radoslav Marinov +5 more
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A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes [PDF]
MoleculesCancer remains one of the leading causes of morbidity and mortality worldwide, driving the search for innovative and selective therapeutic agents. Topoisomerases I and II are essential enzymes involved in key cellular processes such as DNA replication ...
François-Xavier Toublet +2 more
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Enantioselective Conjugate Addition of Diethylzinc to Chalcones Catalysed by Chiral Ni(II) Aminoalcohol Complexes [PDF]
, 1994 Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac)2 and cis-exo-N,N-dialkyl-3-aminoisoborneols or (+)-cis-endo-N,N-dimethyl-3-aminoborneol ((+)-DAB) (13b).
Feringa, Bernard +2 more
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Synthesis of bis-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines [PDF]
MoleculesChalcone is an aromatic ketone that forms the central core of many important biological compounds. Chalcone derivatives show various biological activities, especially anti-inflammatory, antibacterial, antioxidant, and anticancer activities, and also ...
Dorota Olender +5 more
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Synthesis, in-vitro antitubercular, antifungal activities and in silico molecular docking study of Chalcone derivatives from 1-(2'-Hydroxyphenyl)-3-(substituted-phenyl)-2-propenone. [PDF]
Microbes and Infectious Diseases, 2023 Background: Tuberculosis (TB) is one of the major global health problems and faced to the increased resistance of Mycobacterium tuberculosis strains against existing antitubercular agents, it is important to look for new antitubercular drugs.
Arnold Mulula +4 more
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Molecules, 2023 Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit
Alby Tom +6 more
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Pharmaceutics, 2022 The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment.
Eduardo A. Veliz +13 more
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