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Nematicide Chalcones Act Synergistically on Caenorhabditis elegans and Meloidogyne incognita Without Disrupting Soil Microbial Diversity and with Limited Toxicity to Human Cells [PDF]

Molecules
Plant Parasitic Nematodes (PPNs), such as Meloidogyne incognita, cause significant agricultural losses worldwide. Conventional nematicides like methyl bromide are being phased out due to environmental and health concerns, prompting the search for safer ...
Alejandro Calderón-Urrea, Shantanu Shinde, Sosse Kendoyan, Vukasin M. Jovanovic, Seungmi Ryu, Carlos A. Tristan   +5 more
doaj   +2 more sources

Pharmacological potential of natural chalcones: a recent studies and future perspective [PDF]

Frontiers in Pharmacology
Chalcones isolated from natural sources are the primary metabolites of numerous biologically intriguing and pharmacologically essential drugs. Chalcones’ pharmacological properties are believed to result from a double bond conjugated to carbonyl ...
Suman Adhikari, Priyatosh Nath, Vishal Kumar Deb, Niranjan Das, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy   +6 more
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Flavonoids, Chalcones, and Their Fluorinated Derivatives—Recent Advances in Synthesis and Potential Medical Applications [PDF]

Molecules
Flavonoids and chalcones, widely recognised for their diverse biological activities, have garnered attention due to their potential therapeutic applications.
Jakub Kubiak, Piotr Szyk, Beata Czarczynska-Goslinska, Tomasz Goslinski   +3 more
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Synthesis and Bioevaluation of Chalcones as Broad-Spectrum Antiviral Compounds Against Single-Stranded RNA Viruses [PDF]

Biomolecules
Chalcones are flavonoid compounds containing an α,β-unsaturated ketone core that are often found in plants and have diverse biological activities including antiviral activity.
Lorael K. M. Kirton, Nasser N. Yousef, Griffith D. Parks, Otto Phanstiel   +3 more
doaj   +2 more sources

The geroprotective potential of chalcones [PDF]

Nature Communications
Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions.
Didac Carmona-Gutierrez, Andreas Zimmermann, Guido Kroemer, Frank Madeo   +3 more
doaj   +2 more sources

A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes [PDF]

Molecules
Cancer remains one of the leading causes of morbidity and mortality worldwide, driving the search for innovative and selective therapeutic agents. Topoisomerases I and II are essential enzymes involved in key cellular processes such as DNA replication ...
François-Xavier Toublet, Aurélie Laurent, Christelle Pouget   +2 more
doaj   +2 more sources

Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production

Molecules, 2023
Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit
Alby Tom, Jisha Jacob, Manoj Mathews, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo, Arunaksharan Narayanankutty   +6 more
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Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier

Pharmaceutics, 2022
The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment.
Eduardo A. Veliz, Anastasiia Kaplina, Sajini D. Hettiarachchi, Athina L. Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L. Abadi, Emel Kirbas Cilingir, Frederic A. Vallejo, Winston M. Walters, Steven Vanni, Roger M. Leblanc, Regina M. Graham   +13 more
doaj   +1 more source

Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones

Medical Sciences Forum, 2022
Chalcones, a class of compounds characterized by two aromatic rings linked through a three carbon α,β-unsaturated carbonyl system, aroused widespread interest due to their (bio)synthesis and broad biological activities.
Rui Pereira, Vera L. M. Silva, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes   +4 more
doaj   +1 more source

Antiviral properties of chalcones and their synthetic derivatives: a mini review [PDF]

Pharmacia, 2020
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions.
Radoslav Marinov, Nadezhda Markova, Stefka Krumova, Kamelia Yotovska, Maya M. Zaharieva, Petia Genova-Kalou   +5 more
doaj   +3 more sources