Results 11 to 20 of about 54,606 (348)
Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies
Molecules, 2023 Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties.
Fernando Ferreira Leite +10 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies.
Bahare Salehi +22 more
doaj +2 more sources
Applied Sciences, 2020 Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures and biological activities. In this paper, two chalcones, (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-
Priscila Teixeira da Silva +15 more
doaj +2 more sources
Pathogens, 2021 Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and
Ahmed M. Zheoat +9 more
doaj +2 more sources
Chalcones: Synthetic Chemistry Follows Where Nature Leads
Biomolecules, 2021 Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring
Hiba A. Jasim +5 more
doaj +2 more sources
Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model [PDF]
Molecules, 2014 [[abstract]]The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological ...
Ajaiyeoba +9 more
core +6 more sources
Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model [PDF]
Molecules, 2013 [[abstract]]The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)”
Chi-Chung Wen +5 more
core +6 more sources
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos +10 more
doaj +2 more sources
The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones
Molecules, 2018 Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly attributed to the presence in the chalcones of the α,β-unsaturated carbonyl system, perceived as a ...
Matheus de Freitas Silva +6 more
doaj +2 more sources
Synthesis of Chalcones Derivatives and Their Biological Activities: A Review
ACS Omega, 2022 Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO–CH=CH–. Due to the presence of a reactive α,β-unsaturated carbonyl group, chalcones and their derivatives possess a wide spectrum of antiproliferative ...
Nadia A. A. Elkanzi +5 more
semanticscholar +1 more source