Results 11 to 20 of about 36,394 (277)

Chalcones and Dihydrochalcones Augment TRAIL-Mediated Apoptosis in Prostate Cancer Cells [PDF]

Molecules, 2010
Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent.
Wojciech Krol, Andrzej Paradysz, Bogdan Mazur, Zenon P. Czuba, Ewelina Szliszka   +4 more
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Progress of isolation, chemical synthesis and biological activities of natural chalcones bearing 2-hydroxy-3-methyl-3-butenyl group

Frontiers in Chemistry, 2022
Chalcones have a three-carbon α,β-unsaturated carbonyl system composed of two phenolic rings. Many chalcones have shown broad spectrum of biological activities with clinical potentials against various diseases.
Jiadai Zhai, Jiadai Zhai, Bingxia Sun, Feng Sang   +3 more
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Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Pharmaceuticals, 2022
Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior ...
Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn   +9 more
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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Molecules, 2021
Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids.
Mithun Rudrapal, Johra Khan, Abdul Aziz Bin Dukhyil, Randa Mohammed Ibrahim Ismail Alarousy, Emmanuel Ifeanyi Attah, Tripti Sharma, Shubham Jagdish Khairnar, Atul Rupchand Bendale   +7 more
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Structural, Vibrational and Electrochemical Analysis and Antibacterial Potential of Isomeric Chalcones Derived from Natural Acetophenone

Applied Sciences, 2020
Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures and biological activities. In this paper, two chalcones, (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-
Priscila Teixeira da Silva, Thiago Sampaio de Freitas, Diniz Maciel Sena, Paulo Nogueira Bandeira, Murilo Ségio da Silva Julião, Emmanuel Silva Marinho, Ana Aline Coêlho Alcanfor, Emanuelle Machado Marinho, Pedro de Lima-Neto, Carlos Emídio Sampaio Nogueira, Henrique Douglas Melo Coutinho, Antonio Linkoln Alves Borges Leal, Humberto Medeiros Barreto, Natália Martins, Alexandre Magno Rodrigues Teixeira, Hélcio Silva dos Santos   +15 more
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Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]

, 2020
Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi, Arkin, Michelle, Cregg, James, Kenyon, Cynthia, Zhai, Yuying, Zhang, Peichuan   +5 more
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Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

Pharmaceutics, 2023
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing ...
Soufyane Hba, Suzan Ghaddar, Hicham Wahnou, Aline Pinon, Riad El Kebbaj, Christelle Pouget, Vincent Sol, Bertrand Liagre, Mounia Oudghiri, Youness Limami   +9 more
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Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors

Journal of Taibah University for Science, 2021
Twelve novel chalcones were synthesized using 2-alkyloxy-naphthaldehydes and Mannich bases of 4-hydroxyacetophenone. The chalcones were characterized using FTIR, 1D and 2D NMR and HRMS spectroscopy.
Ghadah Aljohani, Adeeb Al-Sheikh Ali, Shaya Y. Alraqa, Syazwani Itri Amran, Norazah Basar   +4 more
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Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
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Advances in the Synthesis of Heteroaromatic Hybrid Chalcones

Molecules, 2023
Chalcones continue to occupy a venerated status as scaffolds for the construction of a variety of heterocyclic molecules with medicinal and industrial properties. Syntheses of hybrid chalcones featuring heteroaromatic components, especially those methods
Ajay Mallia, Joseph Sloop
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