Results 11 to 20 of about 53,724 (334)
Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies
Molecules, 2023 Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties.
Fernando Ferreira Leite +10 more
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Frontiers in Pharmacology, 2021 Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies.
Bahare Salehi +22 more
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Applied Sciences, 2020 Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures and biological activities. In this paper, two chalcones, (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-
Priscila Teixeira da Silva +15 more
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Chalcones: Synthetic Chemistry Follows Where Nature Leads
Biomolecules, 2021 Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring
Hiba A. Jasim +5 more
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Pathogens, 2021 Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and
Ahmed M. Zheoat +9 more
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Chalcones and Dihydrochalcones Augment TRAIL-Mediated Apoptosis in Prostate Cancer Cells [PDF]
Molecules, 2010 Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent.
Almasan +24 more
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Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model [PDF]
Molecules, 2014 [[abstract]]The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological ...
Ajaiyeoba +9 more
core +6 more sources
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos +10 more
doaj +2 more sources
Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model [PDF]
Molecules, 2013 [[abstract]]The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)”
Chi-Chung Wen +5 more
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Enantioselective Conjugate Addition of Diethylzinc to Chalcones Catalysed by Chiral Ni(II) Aminoalcohol Complexes [PDF]
, 1994 Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac)2 and cis-exo-N,N-dialkyl-3-aminoisoborneols or (+)-cis-endo-N,N-dimethyl-3-aminoborneol ((+)-DAB) (13b).
Feringa, Bernard +2 more
core +4 more sources