Results 21 to 30 of about 53,724 (334)

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

Molecules, 2018
Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly attributed to the presence in the chalcones of the α,β-unsaturated carbonyl system, perceived as a ...
Matheus de Freitas Silva, Letizia Pruccoli, Fabiana Morroni, Giulia Sita, Francesca Seghetti, Claudio Viegas, Andrea Tarozzi   +6 more
doaj   +2 more sources

Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production

Molecules, 2023
Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit
Alby Tom, Jisha Jacob, Manoj Mathews, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo, Arunaksharan Narayanankutty   +6 more
doaj   +1 more source

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

ACS Omega, 2022
Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO–CH=CH–. Due to the presence of a reactive α,β-unsaturated carbonyl group, chalcones and their derivatives possess a wide spectrum of antiproliferative ...
Nadia A. A. Elkanzi, Hajer Hrichi, Ruba A. Alolayan, W. Derafa, F. Zahou, R. Bakr   +5 more
semanticscholar   +1 more source

Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier

Pharmaceutics, 2022
The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment.
Eduardo A. Veliz, Anastasiia Kaplina, Sajini D. Hettiarachchi, Athina L. Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L. Abadi, Emel Kirbas Cilingir, Frederic A. Vallejo, Winston M. Walters, Steven Vanni, Roger M. Leblanc, Regina M. Graham   +13 more
doaj   +1 more source

Antiviral properties of chalcones and their synthetic derivatives: a mini review [PDF]

Pharmacia, 2020
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions.
Radoslav Marinov, Nadezhda Markova, Stefka Krumova, Kamelia Yotovska, Maya M. Zaharieva, Petia Genova-Kalou   +5 more
doaj   +3 more sources

Synthesis, in-vitro antitubercular, antifungal activities and in silico molecular docking study of Chalcone derivatives from 1-(2'-Hydroxyphenyl)-3-(substituted-phenyl)-2-propenone. [PDF]

Microbes and Infectious Diseases, 2023
Background:  Tuberculosis (TB) is one of the major global health problems and faced to the increased resistance of Mycobacterium tuberculosis strains against existing antitubercular agents, it is important to look for new antitubercular drugs.
Arnold Mulula, Abdeldjalil Bouzina, Hugues Mambu, Gracia Mbiye, Ahmed Zaki   +4 more
doaj   +1 more source

The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]

Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020
Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting, Charlie L. Hall, Jason Potticary, Natalie E. Pridmore, Stephen D. Warren, Matthew E. Cremeens, Gemma D. D'Ambruoso, Masaomi Matsumoto, Simon R. Hall   +8 more
openaire   +5 more sources

Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones

Medical Sciences Forum, 2022
Chalcones, a class of compounds characterized by two aromatic rings linked through a three carbon α,β-unsaturated carbonyl system, aroused widespread interest due to their (bio)synthesis and broad biological activities.
Rui Pereira, Vera L. M. Silva, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes   +4 more
doaj   +1 more source

Anticancer Activity of Natural and Synthetic Chalcones

International Journal of Molecular Sciences, 2021
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells.
T. Constantinescu, C. Lungu
semanticscholar   +1 more source

Progress of isolation, chemical synthesis and biological activities of natural chalcones bearing 2-hydroxy-3-methyl-3-butenyl group

Frontiers in Chemistry, 2022
Chalcones have a three-carbon α,β-unsaturated carbonyl system composed of two phenolic rings. Many chalcones have shown broad spectrum of biological activities with clinical potentials against various diseases.
Jiadai Zhai, Jiadai Zhai, Bingxia Sun, Feng Sang   +3 more
doaj   +1 more source