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Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence
International Journal of Molecular Sciences, 2023 There is no doubt that significant progress has been made in tumor therapy in the past decades. However, the discovery of new molecules with potential antitumor properties still remains one of the most significant challenges in the field of anticancer ...
Radka Michalková +6 more
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The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020 Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting +8 more
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Chalcones and Gastrointestinal Cancers: Experimental Evidence
International Journal of Molecular Sciences, 2023 Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery, chemotherapy or radiotherapy has several limitations such as drug toxicity, cancer ...
Radka Michalková +5 more
semanticscholar +1 more source
Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones
Medical Sciences Forum, 2022 Chalcones, a class of compounds characterized by two aromatic rings linked through a three carbon α,β-unsaturated carbonyl system, aroused widespread interest due to their (bio)synthesis and broad biological activities.
Rui Pereira +4 more
doaj +1 more source
Anticancer Activity of Natural and Synthetic Chalcones
International Journal of Molecular Sciences, 2021 Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells.
T. Constantinescu, C. Lungu
semanticscholar +1 more source
Frontiers in Chemistry, 2022 Chalcones have a three-carbon α,β-unsaturated carbonyl system composed of two phenolic rings. Many chalcones have shown broad spectrum of biological activities with clinical potentials against various diseases.
Jiadai Zhai +3 more
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Antibiotics, 2022 Naringenin and its glycosylated derivative naringin are flavonoids that are synthesized by the phenylpropanoid pathway in plants. We found that naringenin is also formed by the actinobacterium Streptomyces clavuligerus, a well-known microorganism used to
J. Martín, P. Liras
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Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Pharmaceuticals, 2022 Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior ...
Gayathri Rajendran +9 more
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Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones
Cancers, 2021 Simple Summary Despite the important progress in cancer treatment in the past decades, the mortality rates in some types of cancer have not significantly decreased.
Radka Michalková +4 more
semanticscholar +1 more source
Expert Review of Clinical Pharmacology, 2021 Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key role in diverse gene expressions responsible for protection against oxidative stress and xenobiotics. Chalcones with a common chemical scaffold of 1,3-diaryl-2-
M. Egbujor +4 more
semanticscholar +1 more source