Results 91 to 100 of about 958,913 (319)

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
core   +1 more source

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

International Journal for Parasitology: Drugs and Drug Resistance
The anthelmintic praziquantel (PZQ) has been used for decades as the clinical therapy for schistosomiasis, and remains the only available drug. As a cheap and effective drug therapy for all human disease-causing Schistosoma species, usage of PZQ ...
Claudia M. Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins, Timothy J.C. Anderson, Duncan J. Berger, Matthew Berriman, Sarah K. Buddenborg, Amaya L. Bustinduy, Frédéric D. Chevalier, James A. Cotton, Thomas Crellen, Stephen R. Doyle, Aidan M. Emery, Julien Kincaid Smith, Safari Kinung'hi, Poppy H.L. Lamberton, Winka Le Clec'h, Eric Ndombi, Tom Pennance, Candia Rowel, Shannan S. Summers, John Vianney Tushabe, Martin Walker, Bonnie L. Webster, Joanne P. Webster, Shona Wilson, Jonathan S. Marchant   +26 more
doaj   +1 more source

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source

A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis. [PDF]

PLoS ONE, 2011
The resting membrane potential of the pacemaker neurons is one of the essential mechanisms underlying rhythm generation. In this study, we described the biophysical properties of an uncharacterized channel (U-type channel) and investigated the role of ...
Tom Z Lu, Zhong-Ping Feng
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Transient receptor potential channels in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro, Wajima, Teruaki, Hara, Yuji, Nishida, Motohiro, Mori, Yasuo   +4 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Kinetic model based on molecular mechanism for action potential

, 2011
The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
core  

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source