Results 71 to 80 of about 11,137,717 (304)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Economic Potential of Mobile Entertainment as an Advertisement Channel
2021 44th International Convention on Information, Communication and Electronic Technology (MIPRO), 2021 Business subjects are constantly searching for new channels of distribution of information towards the consumers. In the majority of cases, this type of communication assumes the gathering of information on consumer habits in order for the business subject to be able to send a commercial message to the consumer at a certain time through the channel in ...
openaire +4 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Understanding the key drivers of and technology related issues associated with going multi-channel [PDF]
, 2012 A multi-channel retail strategy is viewed by many academics and practitioners to be the success model for most retailers. Yet, while there are many drivers of, and advantages related to, using multiple channels to sell products and services to customers ...
Whysall, P +5 more
core
The Inhibition of Inwardly Rectifying K+ Channels by Memantine in Macrophages and Microglial Cells
Cellular Physiology and Biochemistry, 2013 Background/Aims: Memantine (MEM) can block N-methyl-D-aspartate receptors non-competitively and is recognized to exert anti-inflammatory action. Whether MEM and other related compounds produce any effects on K+ currents in macrophages and in microglial ...
Ke-Li Tsai +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]
, 2007 ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core
Advances on the calcium channel TRPV6 and associated diseases
生物医学转化, 2021 Transient receptor potential channel subfamily V member 6 (TRPV6) , is a highly selective channel for calcium and is expressed in various tissues where it has a role in importing calcium ion through the apical membrane and plays an important role in ...
Wang Yuanchen, Zou Wenbin, Liao Zhuan
doaj +1 more source
Focusing in multiwell potentials: Applications to ion channels
Physical Review E, 2013 We investigate out of equilibrium stationary distributions induced by a stochastic dichotomous noise on double and multi-well models for ion channels. Ion-channel dynamics is analyzed both through over-damped Langevin equations and master equations. As a consequence of the external stochastic noise, we prove a non trivial focusing effect, namely the ...
Ponzoni, Luca +4 more
openaire +4 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source