Results 61 to 70 of about 11,137,717 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effect of chronic constriction injury after a period of endurance training on the expression of TRPC1 and TRPC3 in the plantaris muscle of male Wistar rats [PDF]

فصلنامه ابن سینا, 2023
Background and aims: Due to the role of TRPC1/3 in muscle atrophy, this study aimed to investigate the effect of Chronic Constriction Injury (CCI) after a period of endurance training on TRPC1/3 gene expression in the plantaris muscle of male Wistar rats.
Abdolreza Kazemi, Hadi Kerendi, Parvaneh Dinarzehi, Naimeh Nekoie   +3 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics

Open Medicine, 2023
Heroin can cause damage to many human organs, possibly leading to different types of arrhythmias and abnormal electrophysiological function of the heart muscle and the steady state of calcium-ion channels.
Su Liping, Liu Li, Ji Min, Hu Xiayun, Liang Min, Lu Ziyang, Wang Zhiguo, Guan Yaling, Xiao Jinling, Zhuang Mengjie, Zhu Sensen, Yang Long, Pu Hongwei   +12 more
doaj   +1 more source

Transient Receptor Potential Channels and Metabolism.

Molecules and cells, 2019
Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
openaire   +2 more sources

TRP channels as potential targets for antischistosomals

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Ion channels are membrane protein complexes that underlie electrical excitability in cells, allowing ions to diffuse through cell membranes in a regulated fashion. They are essential for normal functioning of the neuromusculature and other tissues. Ion channels are also validated targets for many current anthelmintics, yet the properties of only a ...
Swarna Bais, Robert M. Greenberg
openaire   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of Ito, IK, and IK1 and Inhibition of ICa‐L in Rat Ventricular Myocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias.
Ying Zhang, Hua Chen, Qingmin Ma, Hui Jia, Hongyu Ma, Zishuo Du, Yan Liu, Xiangjian Zhang, Yi Zhang, Yue Guan, Huijie Ma   +10 more
doaj   +1 more source

A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression

Exploration of Targeted Anti-tumor Therapy, 2021
Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process.
Wen-Li Hsu, Mami Noda, Tohru Yoshioka, Etsuro Ito   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source