Results 61 to 70 of about 2,617,838 (299)
Transient Receptor Potential Channels and Metabolism.
Molecules and cells, 2019 Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
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Calcium Channel Blockers: Potential Antimetastatic Agents
Experimental Biology and Medicine, 1983 The calcium channel blocker nifedipine (Bay A 1040) was examined for its effects on tumor cell-platelet interactions. In vitro, nifedipine inhibited tumor cell-induced platelet aggregation and platelet enhanced tumor cell adhesion to confluent endothelial cell monolayers and in vivo nifedipine inhibited pulmonary tumor colony formation ("experimental ...
Honn, K V +3 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias.
Ying Zhang +10 more
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The Inhibition of Inwardly Rectifying K+ Channels by Memantine in Macrophages and Microglial Cells
Cellular Physiology and Biochemistry, 2013 Background/Aims: Memantine (MEM) can block N-methyl-D-aspartate receptors non-competitively and is recognized to exert anti-inflammatory action. Whether MEM and other related compounds produce any effects on K+ currents in macrophages and in microglial ...
Ke-Li Tsai +2 more
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Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]
, 1988 We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core
How ion channels sense membrane potential [PDF]
Proceedings of the National Academy of Sciences, 2005 Understanding the inner workings of an ion channel has, in the last several years, boiled down to a hunt for dynamic structural cartoons that capture the essence of the channel's biophysical behavior. The main approach to this end has been the “structure–function” study in which selected residues are mutated and the functional consequences are explored
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Advances on the calcium channel TRPV6 and associated diseases
生物医学转化, 2021 Transient receptor potential channel subfamily V member 6 (TRPV6) , is a highly selective channel for calcium and is expressed in various tissues where it has a role in importing calcium ion through the apical membrane and plays an important role in ...
Wang Yuanchen, Zou Wenbin, Liao Zhuan
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Non-localities in nucleon-nucleus potentials
, 2007 Two causes of non-locality inherent in nucleon-nucleus scattering are considered. They are the results of two-nucleon antisymmetry of the projectile with each nucleon in the nucleus and the dynamic polarization potential representation of channel ...
Amos +30 more
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