Results 81 to 90 of about 2,617,838 (299)

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

Toxins, 2012
Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution ...
Jeffrey R. McArthur, Oliver Knapp, David J. Adams   +2 more
doaj   +1 more source

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. [PDF]

, 2000
A 2 P domain potassium channel expressed in eye, lung, and stomach, Kcnk8, has recently been identified. To initiate further biochemical and genetic studies of this channel, we assembled the murine Kcnk8 cDNA sequence, characterized the genomic structure
Bockenhauer, D, Gallagher, PG, Goldstein, SA, Nimmakayalu, MA, Ward, DC   +4 more
core   +1 more source

Transient receptor potential channels in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro, Wajima, Teruaki, Hara, Yuji, Nishida, Motohiro, Mori, Yasuo   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

3-dimensional electrode patterning within a microfluidic channel using metal ion implantation [PDF]

, 2010
The application of electrical fields within a microfluidic channel enables many forms of manipulation necessary for lab-on-a-chip devices. Patterning electrodes inside the microfluidic channel generally requires multi-step optical lithography.
Adleman, James R., Choi, Jae-Woo, Niklaus, Muhamed, Psaltis, Demetri, Rosset, Samuel, Shea, Herbert   +5 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transition from single-file to two-dimensional diffusion of interacting particles in a quasi-one-dimensional channel

, 2012
Diffusive properties of a monodisperse system of interacting particles confined to a \textit{quasi}-one-dimensional (Q1D) channel are studied using molecular dynamics (MD) simulations.
Farias, G. A., Ferreira, W. P., Lucena, D., Misko, V. R., Nelissen, K., Peeters, F. M., Tkachenko, D. V.   +6 more
core   +1 more source

Adaptive delayed channel access for IEEE 802.11n WLANs [PDF]

, 2008
— In this paper we investigate potential benefits that an adaptive delayed channel access algorithm can attain for the next-generation wireless LANs, the IEEE 802.11n.
Borg, K, Min, G, Ni, Q, Skordoulis, D
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Firing Pattern Formation by Transient Calcium Current in Model Motoneuron

Nonlinear Analysis, 2000
Firing properties of neurons are important in signal detection and generation in nervous system. Spinal cord motoneurons have membrane properties adapted to muscle properties.
N. Svirskienė, G. Svirskis
doaj   +1 more source