Results 11 to 20 of about 2,617,838 (299)
Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment
Frontiers in Oncology, 2021 We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and
Gulimirerouzi Fnu, Georg F. Weber
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Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases
Frontiers in Physiology, 2022 Astrocytes play an important role in the central nervous system (CNS). Ion channels in these cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but also participate in physiological processes of neurons and glial ...
Sijian Wang +5 more
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Na+/Ca2+ selectivity in the bacterial voltage-gated sodium channel NavAb [PDF]
PeerJ, 2013 The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated.
Ben Corry
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Eag1 Channels as Potential Cancer Biomarkers [PDF]
Sensors, 2012 Cancer is a leading cause of death worldwide. New early tumor markers are needed to treat the disease at curable stages. In addition, new therapeutic targets are required to treat patients not responding to available treatments. Ion channels play major roles in health and disease, including cancer.
Javier Camacho +2 more
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mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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Oncogenic potential of EAG K+ channels [PDF]
The EMBO Journal, 1999 We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed ...
L A, Pardo +6 more
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Transient receptor potential channels meet phosphoinositides [PDF]
The EMBO Journal, 2008 Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca(2+) and Mg(2+) homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of
Nilius, Bernd +2 more
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Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities
Biomolecules, 2022 Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation.
Hong-Yu Liang +6 more
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CO2-dependent opening of an inwardly rectifying K+ channel [PDF]
, 2011 CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Huckstepp, Robert T. R., Dale, Nicholas
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Transient Receptor Potential Channels and Itch
International Journal of Molecular Sciences, 2022 Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are abundant in the skin and are involved in the sensory pathways of itch, pain, and inflammation. In this review article, we explore the complex physiology of different TRP channels, their role in modulating itch sensation, and their contributions to the ...
Mahmoud, Omar +2 more
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