Results 261 to 270 of about 11,137,717 (304)

Ion channels and postsynaptic potentials

Biophysical Chemistry, 1988
Neurotransmitters open transmembrane ion channels in target membranes. At the motor endplate, the open time of channels activated by acetylcholine determines the time course of the endplate current. Endplate channels are selective for cations and their conductance and open times are influenced by the nature of the permeating cation.
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Coupled-channel potential for nucleons and deltas

Physical Review C, 1993
We propose a nucleon-nucleon potential for which the [ital NN], [ital N][Delta], and [Delta][Delta] channels are coupled by energy-independent, nonlocal interactions constructed from meson-exchange interactions. The same vertex couplings that were utilized in earlier studies based on the Bonn single-channel [ital NN] potential are adopted. We arrive at
, Haidenbauer, , Holinde, , Johnson
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Effect of channel geometry on the electrostatic potential in acetylcholine channels

Mathematical Biosciences, 2003
We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary.
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Transient Receptor Potential Channels and Mechanosensation

Annual Review of Neuroscience, 2013
Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with ...
Niels, Eijkelkamp, Kathryn, Quick, John N, Wood   +2 more
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TRP Channel Antagonists as Potential Antitussives

Lung, 2011
Cough is a troublesome symptom associated with many respiratory diseases. In some instances cough can become prolonged and excessive, and chronic cough of various aetiologies is a common presentation to specialist respiratory clinics. However, current treatment options are limited.
Megan S, Grace, Eric, Dubuis, Mark A, Birrell, Maria G, Belvisi   +3 more
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Interatomic potential and channelling

Radiation Effects, 1976
Abstract An interatomic potential proposed recently in connection with some planar channelling calculations has been examined with regards to its predictions for the quantities of interest in axial channeling, such as string potential and critical angles.
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Calcium channel as a potential anticancer agent

Medical Hypotheses, 2009
Anticancer treatment in modern clinical practices includes chemotherapy and radiation therapy with or without surgical interventions. Efficiency of both methods varies greatly depending on cancer types and stages. Besides, chemo- and radiotherapy are toxic and damaging that causes serious side effects.
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The pharmacology of potassium channels and their therapeutic potential

Trends in Pharmacological Sciences, 1988
Abstract In the last few years, evidence has emerged that the cellular site of action of a number of drugs used therapeutically seems to involve the modulation of membrane K + channels. For example, blockers of K + channels are able to promote the secretion of insulin from the pancreas and to suppress dysrhythmias of the heart.
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Ion Channels in Action Potential Generation

Hospital Practice, 1992
Molecular structure-function studies have identified the two key regions--the voltage sensor and pore--of the sodium and potassium channels responsible for the action potential in nerve axon. Mutational analysis has focused on the amino acids that are most important in each region. Similar studies in myocytes and nerve cell bodies are now being pursued.
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The h-channel: A potential channelopathy in epilepsy?

Epilepsy & Behavior, 2005
Ion channelopathy is a proven cause of inherited human epilepsy, and may play a role in acquired epileptic syndromes as well. Of the many ion channel causes of epilepsy, the h-channel is a potential new addition. H-channels are voltage-gated ion channels with unique biophysical properties.
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