Results 61 to 70 of about 2,601,570 (295)

Transient Receptor Potential Channels and Metabolism.

Molecules and cells, 2019
Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
openaire   +2 more sources

Calcium Channel Blockers: Potential Antimetastatic Agents

Experimental Biology and Medicine, 1983
The calcium channel blocker nifedipine (Bay A 1040) was examined for its effects on tumor cell-platelet interactions. In vitro, nifedipine inhibited tumor cell-induced platelet aggregation and platelet enhanced tumor cell adhesion to confluent endothelial cell monolayers and in vivo nifedipine inhibited pulmonary tumor colony formation ("experimental ...
Honn, K V, Onoda, J M, Diglio, C A, Sloane, B F   +3 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Advances on the calcium channel TRPV6 and associated diseases

生物医学转化, 2021
Transient receptor potential channel subfamily V member 6 (TRPV6) , is a highly selective channel for calcium and is expressed in various tissues where it has a role in importing calcium ion through the apical membrane and plays an important role in ...
Wang Yuanchen, Zou Wenbin, Liao Zhuan
doaj   +1 more source

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

Multi-Channel Inverse Scattering Problem on the Line: Thresholds and Bound States [PDF]

, 2003
We consider the multi-channel inverse scattering problem in one-dimension in the presence of thresholds and bound states for a potential of finite support.
C.V. Sukumar, C.V. Sukumar, C.V. Sukumar, D. Baye, D. Baye, E. Witten, F. Calogero, F. Calogero, H. Leeb, H. Leeb, H.A. Weidenmüller, I. Kay, J. Kasper, J.-M. Sparenberg, L. Infeld, M. Braun, M. Braun, M. Wadati, M.V. Klibanov, R.D. Amado, R.D. Amado, R.E. Burge, S. A. Sofianos, S.A. Sofianos   +23 more
core   +2 more sources

How ion channels sense membrane potential [PDF]

Proceedings of the National Academy of Sciences, 2005
Understanding the inner workings of an ion channel has, in the last several years, boiled down to a hunt for dynamic structural cartoons that capture the essence of the channel's biophysical behavior. The main approach to this end has been the “structure–function” study in which selected residues are mutated and the functional consequences are explored
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

BioMedical Engineering OnLine, 2018
Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
doaj   +1 more source