Results 81 to 90 of about 2,601,570 (295)

Transient receptor potential channels in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro, Wajima, Teruaki, Hara, Yuji, Nishida, Motohiro, Mori, Yasuo   +4 more
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source

A Formulation of the Potential for Communication Condition using C2KA

, 2014
An integral part of safeguarding systems of communicating agents from covert channel communication is having the ability to identify when a covert channel may exist in a given system and which agents are more prone to covert channels than others. In this
Jaskolka, Jason, Khedri, Ridha
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam

International Journal for Parasitology: Drugs and Drug Resistance
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues ...
Claudia M. Rohr, Paul McCusker, Marc Kaethner, Rebecca Armstrong, Emily Robb, Sang-Kyu Park, Daniel J. Sprague, Aaron G. Maule, Mostafa Zamanian, Britta Lundström-Stadelmann, John D. Chan, Jonathan S. Marchant   +11 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Control of cation permeation through the nicotinic receptor channel. [PDF]

PLoS Computational Biology, 2008
We used molecular dynamics (MD) simulations to explore the transport of single cations through the channel of the muscle nicotinic acetylcholine receptor (nAChR).
Hai-Long Wang, Xiaolin Cheng, Palmer Taylor, J Andrew McCammon, Steven M Sine   +4 more
doaj   +1 more source

Multiparty Quantum Communication Using Multiqubit Entanglement and Teleportation [PDF]

, 2014
We propose a 2N qubit entangled channel that can be used to teleport N qubits in a network to a single receiver. We describe the structure of this channel and explicitly demonstrate how the protocol works. The channel can be used to implement a scheme in
Ghose, Shohini, Hamel, Angele M., Kumar, Atul   +2 more
core   +1 more source