Results 141 to 150 of about 58,886,902 (260)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Überblick Bundestag Jugend-Check zum Entwurf eines Gesetzes zur Stärkung der nationalen Suizidprävention (Kabinettsbefassung: 18.12.2024) [PDF]

open access: yes
Der „Überblick Bundestag“ wird bei Jugend-Checks erstellt, bei welchen der Gesetzentwurf in der Kabinettsfassung vorliegt. Das bedeutet, dass dieser Gesetzentwurf in der vorliegenden Fassung im Bundestag diskutiert werden wird.
Kompetenzzentrum Jugend-Check
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Überblick Bundestag Jugend-Check zum Entwurf eines Gesetzes zur Modernisierung des Bundespolizeigesetzes (Kabinettsbefassung: 08.10.2025) [PDF]

open access: yes
Der „Überblick Bundestag“ wird bei Jugend-Checks erstellt, bei welchen der Gesetzentwurf in der Kabinettsfassung vorliegt. Das bedeutet, dass dieser Gesetzentwurf in der vorliegenden Fassung im Bundestag diskutiert werden wird.
Kompetenzzentrum Jugend-Check
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Überblick Bundestag Jugend-Check zum Entwurf eines Gesetzes zur Anpassung der Krankenhausreform (Krankenhausreformanpassungsgesetz – KHAG) (Kabinettsbefassung: 08.10.2025) [PDF]

open access: yes
Der „Überblick Bundestag“ wird bei Jugend-Checks erstellt, bei welchen der Gesetzentwurf in der Kabinettsfassung vorliegt. Das bedeutet, dass dieser Gesetzentwurf in der vorliegenden Fassung im Bundestag diskutiert werden wird.
Kompetenzzentrum Jugend-Check
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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