Results 1 to 10 of about 478,848 (342)

BRG1 Mediates Nephronectin Activation in Hepatocytes to Promote T Lymphocyte Infiltration in ConA-Induced Hepatitis

Frontiers in Cell and Developmental Biology, 2021
Fulminant hepatitis (FH) is a major cause of acute liver failure. Concanavalin A (ConA) belongs to the lectin family and is frequently used as an inducer of FH in animal models. ConA induced FH is characterized by massive accumulation of T lymphocytes in
Wenxuan Hong, Ming Kong, Mengwen Qi, Hui Bai, Zhiwen Fan, Zhiwen Fan, Ziyu Zhang, Ziyu Zhang, Aijun Sun, Xiangshan Fan, Yong Xu, Yong Xu   +11 more
doaj   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Luckow, Bruno, Mack, Matthias, Schlöndorff, Detlef, Vielhauer, Volker   +5 more
core   +1 more source

Chemokine CCL4 Induced in Mouse Brain Has a Protective Role against Methylmercury Toxicity

Toxics, 2018
Methylmercury (MeHg) is selectively toxic to the central nervous system, but mechanisms related to its toxicity are poorly understood. In the present study, we identified the chemokine, C-C motif Chemokine Ligand 4 (CCL4), to be selectively upregulated ...
Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Masatake Fujimura, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang   +6 more
doaj   +1 more source

Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes

Frontiers in Pharmacology, 2020
In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many of ...
Tadashi Hosoya, Tadashi Hosoya, Nikunj M. Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald S. Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi, Maripat Corr   +11 more
doaj   +1 more source

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +2 more sources

The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

Frontiers in Immunology, 2019
Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread.
Andrew O. Yam, Andrew O. Yam, Tatyana Chtanova, Tatyana Chtanova   +3 more
doaj   +1 more source

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +4 more sources

Low hemagglutinin antigen dose influenza vaccines adjuvanted with AS03 alter the long-term immune responses in BALB/c mice

Human Vaccines & Immunotherapeutics, 2017
We investigated the long-term immune profiles of dose-sparing, AS03-adjuvanted vaccines compared to a traditional high-dose, unadjuvated influenza vaccine formulation.
Karen K. Yam, Angela Brewer, Virginie Bleau, Édith Beaulieu, Corey P. Mallett, Brian J. Ward   +5 more
doaj   +1 more source

Synergistic Induction of Eotaxin and VCAM-1 Expression in Human Corneal Fibroblasts by Staphylococcal Peptidoglycan and Either IL-4 or IL-13

Allergology International, 2011
Background: Common features of allergic or atopic ocular and skin diseases are the participation of Th2 lymphocytes and eosinophils and colonization by Staphylococcus aureus. To examine the role of interaction between Th2 cells and bacterial infection in
Ken Fukuda, Teruo Nishida, Atsuki Fukushima   +2 more
doaj   +1 more source

CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]

, 2019
Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank, Burggraf, Manja, Gonzalez Menendez, Irene, Iwakura, Yoichiro, Kato, Yoichiro, Kirberg, Jörg, Krause, Maren, Laiño, Jonathan Emiliano, Martella, Manuela, Ohbayashi, Masaharu, Quintanilla Martinez, Leticia, Scheurer, Stephan, Shibata, Noriyuki, Toda, Masako, Vieths, Stefan   +14 more
core   +1 more source