Results 1 to 10 of about 501,020 (195)
Frontiers in Immunology, 2022 Sphingolipids, ceramides and cholesterol are integral components of cellular membranes, and they also play important roles in signal transduction by regulating the dynamics of membrane receptors through their effects on membrane fluidity.
Sofía R. Gardeta +12 more
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Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
eLife, 2022 Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz +12 more
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Frontiers in Immunology, 2022 Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow +5 more
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Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells
Journal of Translational Medicine, 2021 Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the treatment of inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory and regenerative potentials. MSCs can be sourced from a variety
Nerea Cuesta-Gomez +2 more
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Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases [PDF]
Iranian Journal of Immunology, 2022 Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific B cells in the germinal center.
Sara Iranparast +8 more
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Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
Nature Communications, 2023 Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple solid cancer types,
Veronika Bandara +25 more
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Frontiers in Immunology, 2023 Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs +7 more
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Diagnostics, 2021 There have been few reports on the kinetics of hemodialyzed (HD) patients’ immune responses in latent tuberculosis infection (LTBI). Therefore, in the present study, messenger ribonucleic acid (mRNA) expression levels of nine immune markers were analyzed
Ji Young Park +5 more
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Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking
EMBO Molecular Medicine, 2023 Alcoholic liver disease (ALD) accounts for a large fraction of patients with cirrhosis and hepatocellular carcinoma. In the present study we investigated the involvement of Brahma‐related gene 1 (Brg1) in ALD pathogenesis and implication in ALD ...
Nan Li +8 more
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Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine
EMBO Molecular Medicine, 2022 We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic development, within the
Sara Caxaria +23 more
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