Results 11 to 20 of about 478,848 (342)

Chemokines [PDF]

Blood, 1997
Barrett J. Rollins
openalex   +4 more sources

Sphingomyelin Depletion Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells

Frontiers in Immunology, 2022
Sphingolipids, ceramides and cholesterol are integral components of cellular membranes, and they also play important roles in signal transduction by regulating the dynamics of membrane receptors through their effects on membrane fluidity.
Sofía R. Gardeta, Eva M. García-Cuesta, Gianluca D’Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Jorge Bernardino de la Serna, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, José Miguel Rodríguez-Frade, Mario Mellado   +12 more
doaj   +1 more source

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

eLife, 2022
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz, Robin Bartolini, Gillian J Wilson, Douglas P Dyer, Francesca Vidler, Catherine E Hughes, Fabian Schuette, Samantha Love, Marieke Pingen, Alan James Hayes, Jun Fu, Adrian Francis Stewart, Gerard J Graham   +12 more
doaj   +1 more source

TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses

Frontiers in Immunology, 2022
Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow, Ervin E. Kara, Timona S. Tyllis, Carola G. Vinuesa, Shaun R. McColl, Iain Comerford   +5 more
doaj   +1 more source

Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells

Journal of Translational Medicine, 2021
Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the treatment of inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory and regenerative potentials. MSCs can be sourced from a variety
Nerea Cuesta-Gomez, Gerard J. Graham, John D. M. Campbell   +2 more
doaj   +1 more source

Accuracy of CCL20 expression level as a liquid biopsy-based diagnostic biomarker for ovarian carcinoma

Frontiers in Oncology, 2022
ObjectiveThe study aimed to investigate the potentiality of chemokines, including MCP-1, CCL15, CCL20, and CXCL14, as biomarkers for differential diagnosis between benign tumors and ovarian cancer (OC).MethodsA cross-sectional study was conducted in ...
Watchara Sakares, Wannaporn Wongkhattiya, Ponlawat Vichayachaipat, Chompunoot Chaiwut, Varalee Yodsurang, Varalee Yodsurang, Pattiya Nutthachote   +6 more
doaj   +1 more source

A network approach to define the predictive role of immune profile on tumor response and toxicity of anti PD-1 single agent immunotherapy in patients with solid tumors

Frontiers in Immunology, 2023
BackgroundThe immune profile of each patient could be considered as a portrait of the fitness of his/her own immune system. The predictive role of the immune profile in immune-related toxicities (irAEs) development and tumour response to treatment was ...
Silvia Mezi, Giulia Pomati, Giulia Fiscon, Sasan Amirhassankhani, Ilaria Grazia Zizzari, Chiara Napoletano, Aurelia Rughetti, Ernesto Rossi, Giovanni Schinzari, Giovanni Schinzari, Giampaolo Tortora, Giampaolo Tortora, Gaetano Lanzetta, Giulia D’Amati, Marianna Nuti, Daniele Santini, Andrea Botticelli   +16 more
doaj   +1 more source

Chemokines [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
It is now well appreciated that chemokines play a fundamental role in various aspects of CVDs (Figure). Although numerous features of chemokine biology in relation to CVD remain to be elucidated, recent studies including those published i ATVB and highlighted herein have substantially contributed to our current knowledge on chemokines.
van der Vorst, Emiel P. C., Doering, Yvonne, Weber, Christian   +2 more
openaire   +2 more sources

Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7

Nature Communications, 2023
Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple solid cancer types,
Veronika Bandara, Jade Foeng, Batjargal Gundsambuu, Todd S. Norton, Silvana Napoli, Dylan J. McPeake, Timona S. Tyllis, Elaheh Rohani-Rad, Caitlin Abbott, Stuart J. Mills, Lih Y. Tan, Emma J. Thompson, Vasiliki M. Willet, Victoria J. Nikitaras, Jieren Zheng, Iain Comerford, Adam Johnson, Justin Coombs, Martin K. Oehler, Carmela Ricciardelli, Allison J. Cowin, Claudine S. Bonder, Michael Jensen, Timothy J. Sadlon, Shaun R. McColl, Simon C. Barry   +25 more
doaj   +1 more source

DNA Hypermethylation-Regulated CX3CL1 Reducing T Cell Infiltration Indicates Poor Prognosis in Wilms Tumour

Frontiers in Oncology, 2022
ObjectiveTo investigate the role of chemokines in Wilms tumours, especially their chemotaxis to immune cells and the role of DNA methylation in regulating the expression level of chemokines.MethodsRNAseqV2 gene expression and clinical data were ...
Tao Mi, Tao Mi, Tao Mi, Liming Jin, Liming Jin, Liming Jin, Zhaoxia Zhang, Zhaoxia Zhang, Zhaoxia Zhang, Jinkui Wang, Jinkui Wang, Jinkui Wang, Mujie Li, Mujie Li, Mujie Li, Chenghao Zhanghuang, Chenghao Zhanghuang, Chenghao Zhanghuang, Xiaojun Tan, Xiaojun Tan, Xiaojun Tan, Zhang Wang, Zhang Wang, Zhang Wang, Xiaomao Tian, Xiaomao Tian, Xiaomao Tian, Bin Xiang, Bin Xiang, Bin Xiang, Dawei He, Dawei He, Dawei He   +32 more
doaj   +1 more source