Results 1 to 10 of about 86,978 (177)

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration [PDF]

Journal of Neuroinflammation, 2022
Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma, Jon P. Niemi, Joel S. Pachter, Richard E. Zigmond   +3 more
doaj   +2 more sources

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

Neoplasia: An International Journal for Oncology Research, 2014
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design ...
Yaeli Lebel-Haziv, Tsipi Meshel, Gali Soria, Adva Yeheskel, Elad Mamon, Adit Ben-Baruch   +5 more
doaj   +2 more sources

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer [PDF]

Frontiers in Pharmacology
Solid tumors present a significant challenge to Chimeric Antigen Receptor (CAR) -T cell therapy, primarily due to limited T-cell infiltration and persistence in the tumor microenvironment.
Raj Kumar, Irva E. Veillard, Mengyao Xu, Linah Al-Alem, Bo R. Rueda, Bo R. Rueda, Oladapo O. Yeku   +6 more
doaj   +2 more sources

Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment. [PDF]

JCI Insight, 2022
Oo MW, Kawai H, Takabatake K, Tomida S, Eguchi T, Ono K, Shan Q, Ohara T, Yoshida S, Omori H, Sukegawa S, Nakano K, Okamoto K, Sasaki A, Nagatsuka H.   +14 more
europepmc   +3 more sources

Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5-year graft failure and mortality post 1-year protocol biopsy in kidney transplant recipients. [PDF]

Immun Inflamm Dis, 2023
Gniewkiewicz M, Gozdowska J, Deborska-Materkowska D, Czerwinska K, Perkowska-Ptasinska A, Burban A, Cieslik A, Kosieradzki M, Durlik M.   +8 more
europepmc   +3 more sources

Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model. [PDF]

Pain, 2022
Zhu X, Xie W, Zhang J, Strong JA, Zhang JM.   +4 more
europepmc   +3 more sources

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. [PDF]

J Neurosci, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, Perry VH, Bozzi Y, Caleo M.   +8 more
europepmc   +4 more sources

Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients. [PDF]

BMC Cancer, 2019
Kishimoto T, Fujimoto N, Ebara T, Omori T, Oguri T, Niimi A, Yokoyama T, Kato M, Usami I, Nishio M, Yoshikawa K, Tokuyama T, Tamura M, Yokoyama Y, Tsuboi K, Matsuo Y, Xu J, Takahashi S, Abdelgied M, Alexander WT, Alexander DB, Tsuda H.   +21 more
europepmc   +5 more sources

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn. [PDF]

J Neuroinflammation, 2021
Heles M, Mrozkova P, Sulcova D, Adamek P, Spicarova D, Palecek J.   +5 more
europepmc   +3 more sources

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +24 more sources