Results 1 to 10 of about 86,546 (282)

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. [PDF]

J Neurosci, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, Perry VH, Bozzi Y, Caleo M.   +8 more
europepmc   +12 more sources

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration [PDF]

Journal of Neuroinflammation, 2022
Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma, Jon P. Niemi, Joel S. Pachter, Richard E. Zigmond   +3 more
doaj   +2 more sources

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer [PDF]

Frontiers in Pharmacology
Solid tumors present a significant challenge to Chimeric Antigen Receptor (CAR) -T cell therapy, primarily due to limited T-cell infiltration and persistence in the tumor microenvironment.
Raj Kumar, Irva E. Veillard, Mengyao Xu, Linah Al-Alem, Bo R. Rueda, Bo R. Rueda, Oladapo O. Yeku   +6 more
doaj   +2 more sources

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +24 more sources

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Cell Discovery, 2022
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen   +21 more
doaj   +1 more source

The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. [PDF]

PLoS ONE, 2012
Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), belongs to the CC chemokine family that is associated with the disease status and outcomes of osteoarthritis (OA).
Yu-Min Lin, Chin-Jung Hsu, Yuan-Ya Liao, Ming-Chih Chou, Chih-Hsin Tang   +4 more
doaj   +1 more source

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma

Cell Death and Disease, 2022
For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing antitumor strategy established on the crucial ...
Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang, Xianyue Ren, Tong Wu, Juan Xia, Bin Cheng, Xiaoan Tao   +10 more
doaj   +1 more source

Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis

Biomedicines, 2023
Osteosarcoma is a common malignant tumor in children and adolescents, known for its aggressive invasion and distant metastasis, leading to a poor prognosis.
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang   +6 more
doaj   +1 more source

Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety

Frontiers in Cellular Neuroscience, 2020
Chemokines such as chemokine (C-C motif) ligand 2 (CCL2) play a role in several behaviors, including anxiety-like behavior, but whether neurons are an important source of CCL2 for behavior and how neuronal CCL2 may work to affect behavior are still ...
Kathryn M. Harper, Kathryn M. Harper, Darin J. Knapp, Darin J. Knapp, Caroline A. Todd, Irina Balan, Irina Balan, Laure Aurelian, Laure Aurelian, Hugh E. Criswell, George R. Breese, George R. Breese, George R. Breese   +12 more
doaj   +1 more source

Clinical significance of CCL2 expression in osteosarcoma tissue [PDF]

Zhongguo aizheng zazhi, 2021
Background and purpose: Osteosarcoma is a primary malignant tumor in bone tissue, mainly in adolescents. The prognosis of patients with lung metastasis is poor.
GONG Runze, HU Haiyan
doaj   +1 more source