CCL2 nitration is a negative regulator of chemokine-mediated inflammation. [PDF]
Scientific Reports, 2017 Chemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO).
Ali, Simi +6 more
core +8 more sources
Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.
PLoS ONE, 2012 Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses.
Ulrich F O Luhmann +11 more
doaj +6 more sources
CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study [PDF]
Cancer Research and Treatment, 2014 Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa.Preoperative and early ...
Igor Tsaur +13 more
openalex +5 more sources
Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. [PDF]
ACS Omega, 2020 An integrated and controlled migration of leukocytes is necessary for the legitimate functioning and maintenance of the immune system. Chemokines and their receptors play a decisive role in regulating the leukocyte migration to the site of inflammation, a phenomena often referred to as chemotaxis.
Joshi N, Kumar D, Poluri KM.
europepmc +5 more sources
A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages. [PDF]
Angew Chem Int Ed Engl, 2019 Fernandez A +4 more
europepmc +2 more sources
Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]
Clinical and Translational Allergy, 2020 AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur +7 more
openaire +3 more sources
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
doaj +1 more source
The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]
Toxicological Sciences, 2011 Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, David +10 more
openaire +4 more sources
The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. [PDF]
PLoS ONE, 2012 Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), belongs to the CC chemokine family that is associated with the disease status and outcomes of osteoarthritis (OA).
Yu-Min Lin +4 more
doaj +1 more source
Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis [PDF]
Fibrogenesis & Tissue Repair, 2011 AbstractBackgroundPulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors.
Vyacheslav Palchevskiy +11 more
openalex +5 more sources