Results 11 to 20 of about 86,546 (282)
CCL2 nitration is a negative regulator of chemokine-mediated inflammation. [PDF]
Scientific Reports, 2017 Chemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO).
Ali, Simi +6 more
core +8 more sources
Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.
PLoS ONE, 2012 Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses.
Ulrich F O Luhmann +11 more
doaj +6 more sources
Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. [PDF]
ACS Omega, 2020 An integrated and controlled migration of leukocytes is necessary for the legitimate functioning and maintenance of the immune system. Chemokines and their receptors play a decisive role in regulating the leukocyte migration to the site of inflammation, a phenomena often referred to as chemotaxis.
Joshi N, Kumar D, Poluri KM.
europepmc +5 more sources
Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]
Clinical and Translational Allergy, 2020 AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur +7 more
openaire +3 more sources
The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]
Toxicological Sciences, 2011 Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, David +10 more
openaire +4 more sources
The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion [PDF]
Molecular Cancer Research, 2015 Abstract Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand–receptor interactions between nerves and cancer cells that support the process of perineural invasion.
Shizhi, He +11 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2014 .: Methamphetamine addiction is characterized by drug craving caused by stimulation of the reward system. Because neuroinflammation underlies several neurological disorders, we investigated whether CC-chemokine ligand 2 (CCL2) participates in the ...
Naoki Wakida +5 more
doaj +1 more source
Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]
, 2013 Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B +2 more
core +2 more sources
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Orthopaedic Surgery, 2023 Objective Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to clarify whether human umbilical cord mesenchymal stem cells (
Shixun Li +9 more
doaj +1 more source