Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
Cell Death and Disease, 2022 For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing antitumor strategy established on the crucial ...
Zihang Ling +10 more
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Prenatal fat-rich diet exposure alters responses of embryonic neurons to the chemokine, CCL2, in the hypothalamus. [PDF]
Neuroscience, 2016 Poon K, Abramova D, Ho HT, Leibowitz S.
europepmc +2 more sources
CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice. [PDF]
PLoS ONE, 2016 Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear.
Xuguang Chen +8 more
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Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis
Biomedicines, 2023 Osteosarcoma is a common malignant tumor in children and adolescents, known for its aggressive invasion and distant metastasis, leading to a poor prognosis.
Yu-Hsiang Chang +6 more
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Clinical significance of CCL2 expression in osteosarcoma tissue [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Osteosarcoma is a primary malignant tumor in bone tissue, mainly in adolescents. The prognosis of patients with lung metastasis is poor.
GONG Runze, HU Haiyan
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The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion [PDF]
Molecular Cancer Research, 2015 Abstract Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand–receptor interactions between nerves and cancer cells that support the process of perineural invasion.
Shizhi, He +11 more
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Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety
Frontiers in Cellular Neuroscience, 2020 Chemokines such as chemokine (C-C motif) ligand 2 (CCL2) play a role in several behaviors, including anxiety-like behavior, but whether neurons are an important source of CCL2 for behavior and how neuronal CCL2 may work to affect behavior are still ...
Kathryn M. Harper +12 more
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CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
mBio, 2022 There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it to elude antivirals and the immune system.
Thomas Packard +16 more
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Journal of Pharmacological Sciences, 2014 .: Methamphetamine addiction is characterized by drug craving caused by stimulation of the reward system. Because neuroinflammation underlies several neurological disorders, we investigated whether CC-chemokine ligand 2 (CCL2) participates in the ...
Naoki Wakida +5 more
doaj +1 more source
Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]
, 2013 Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B +2 more
core +2 more sources