Orthopaedic Surgery, 2023 Objective Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to clarify whether human umbilical cord mesenchymal stem cells (
Shixun Li +9 more
doaj +1 more source
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
, 2006 Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
core +1 more source
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor
Virology, 2010 Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma (KS), an endothelial cell lesion believed to be initiated and driven primarily by cytokine dysregulation. Among the viral proteins suspected as contributing to viral pathogenesis is the lytically expressed viral G protein-coupled receptor (vGPCR), which can induce various cellular ...
Choi, Young Bong, Nicholas, John
openaire +2 more sources
Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2 [PDF]
The Journal of Experimental Medicine, 2004 CD1d-restricted Vα24-Jα18–invariant natural killer T cells (iNKTs) are potentially important in tumor immunity. However, little is known about their localization to tumors. We analyzed 98 untreated primary neuroblastomas from patients with metastatic disease (stage 4) for tumor-infiltrating iNKTs using TaqMan® reverse transcription polymerase chain ...
Metelitsa, Leonid S. +8 more
openaire +2 more sources
The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation
JCI Insight, 2022 Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the ...
Rami Bechara +7 more
doaj +1 more source
Predictive value of CCL2 in the prognosis and immunotherapy response of glioblastoma multiforme
BMC Genomics, 2023 Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a poor prognosis. The C-C motif chemokine ligand 2 (CCL2) has shown abnormal expression associated with progression of multiple malignancies, however, its ...
Longfei Deng +6 more
doaj +1 more source
CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation
Frontiers in Cell and Developmental Biology, 2023 Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment.
Masakazu Toya +9 more
doaj +1 more source
TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]
, 2016 Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin +53 more
core +2 more sources
Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim +2 more
core +1 more source