Results 31 to 40 of about 86,546 (282)

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

PLoS Biology, 2019
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee, Gillian J Wilson, Marieke Pingen, Ayumi Fukuoka, Christopher A H Hansell, Robin Bartolini, Laura Medina-Ruiz, Gerard J Graham   +7 more
doaj   +1 more source

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD

PLoS ONE, 2014
The chemokine receptors CX3CR1 and CCR2 have been implicated in the development of age-related macular degeneration (AMD). The evidence is mainly derived from experimental cell studies and murine models of AMD. The purpose of this study was to investigate the association between expression of CX3CR1 and CCR2 on different leukocyte subsets and AMD ...
Falk, Mads Krüger, Singh, Amardeep, Faber, Carsten, Nissen, Mogens Holst, Hviid, Thomas, Sørensen, Torben Lykke   +5 more
openaire   +5 more sources

The effect of C–C motif chemokine ligand 2 supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation

Frontiers in Veterinary Science, 2023
Porcine embryos are used for a variety of applications. However, the maturation rate in vitro remains low, and novel in vitro maturation (IVM) techniques that facilitate the collection of mature oocytes are necessary.
Sohee Kim, Sohee Kim, Dongjin Oh, Dongjin Oh, Hyerin Choi, Hyerin Choi, Mirae Kim, Mirae Kim, Lian Cai, Lian Cai, Lian Cai, Ali Jawad, Ali Jawad, Zheng Haomiao, Zheng Haomiao, Joohyeong Lee, Joohyeong Lee, Eunhye Kim, Sang-Hwan Hyun, Sang-Hwan Hyun, Sang-Hwan Hyun   +20 more
doaj   +1 more source

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

Neoplasia: An International Journal for Oncology Research, 2014
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design ...
Yaeli Lebel-Haziv, Tsipi Meshel, Gali Soria, Adva Yeheskel, Elad Mamon, Adit Ben-Baruch   +5 more
doaj   +1 more source

Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2 [PDF]

Journal of Interferon & Cytokine Research, 2014
The molecular cross-talk between epithelium and immune cells in the airway mucosa is a key regulator of homeostatic immune surveillance and is crucially involved in the development of chronic lung inflammatory diseases. The patterns of gene expression that follow the sensitization process occurring in allergic asthma and chronic rhinosinusitis and ...
Ronaldo P. Panganiban, Becky M. Vonakis, Faoud T. Ishmael, STELLATO, Cristiana   +3 more
openaire   +3 more sources

Chemokines in ICU Delirium: An Exploratory Study

Critical Care Explorations, 2022
OBJECTIVES:. The pathophysiology of delirium is complex and incompletely understood. Inflammation is hypothesized to be integral to its development due to effects on blood brain barrier integrity, facilitation of leukocyte extravasation into brain ...
Ryan J. Smith, MD, JD, Alejandro A. Rabinstein, MD, Rodrigo Cartin-Ceba, MD, MSc, Vijay P. Singh, MBBS, MD, Christian Lachner, MD, Biswajit Khatua, PhD, Shubham Trivedi, BS, Ognjen Gajic, MD   +7 more
doaj   +1 more source

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases [PDF]

Biomedical Papers, 2006
Chemokines and chemokine receptors are major mediators of leukocyte trafficking into the sites of the immune response. They participate in defence against microbial infection, in Th1/Th2 polarization of the immune response, allograft rejection and angiogenesis/angiostasis as well as in tumorigenesis and metastasis.
openaire   +2 more sources

CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis [PDF]

Cytokine & Growth Factor Reviews, 2010
CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation. A growing body of research suggests CCL2 is progressively overexpressed in tumor beds and may play a role in the clinical progression of solid tumors. Cancer cells derived from several solid tumor types demonstrate functional receptors for CCL2, suggesting this ...
Jian, Zhang, Lalit, Patel, Kenneth J, Pienta   +2 more
openaire   +2 more sources