Results 41 to 50 of about 86,546 (282)

CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice.

PLoS ONE, 2016
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear.
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins   +8 more
doaj   +1 more source

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
core   +2 more sources

Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus [PDF]

Journal of Translational Medicine, 2014
حتى في عصر الجمع الناجح بين العلاج المضاد للفيروسات القهقرية (CART)، لا تزال العدوى المشتركة بفيروس التهاب الكبد الوبائي (HCV) أحد الأسباب الرئيسية للوفيات والمراضة غير المرتبطة بالإيدز بين الأفراد المصابين بفيروس نقص المناعة البشرية نتيجة لتسارع تليف الكبد ومرض الكبد في المرحلة النهائية (ESLD).
Abdul W. Ansari, Reinhold E. Schmidt, Esaki M. Shankar, Adeeba Kamarulzaman   +3 more
openaire   +2 more sources

In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

Journal of Translational Medicine, 2011
Background Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors.
Meropol Neal J, Mastrangelo Michael, Gross Laura, Zhang Tianqian, Rani Pyapalli, Berencsi Klara, Herlyn Dorothee, Somasundaram Rajasekharan   +7 more
doaj   +1 more source

Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Frontiers in Immunology, 2020
Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo.
Daniela Angela Covino, Karolina Elżbieta Kaczor-Urbanowicz, Karolina Elżbieta Kaczor-Urbanowicz, Jing Lu, Maria Vincenza Chiantore, Gianna Fiorucci, Gianna Fiorucci, Maria Fenicia Vescio, Laura Catapano, Cristina Purificato, Clementina Maria Galluzzo, Roberta Amici, Mauro Andreotti, Maria Cristina Gauzzi, Matteo Pellegrini, Laura Fantuzzi   +15 more
doaj   +1 more source

The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects [PDF]

BIO Web of Conferences
Excess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and ...
Lestarini Asri, Aryastuti Anak Agung Sri Agung, Witari Ni Putu Diah, Dewi Ni Wayan Erly Sintya   +3 more
doaj   +1 more source

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

mBio, 2022
There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it to elude antivirals and the immune system.
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene   +16 more
openaire   +4 more sources

Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]

, 2017
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario, Braghetta, Paola, Bressan, Giorgio M., Carnevale, Daniela, Carnevale, Lorenzo, Carnevale, Raimondo, Casaburo, Manuel, Cifelli, Giuseppe, DA ROS, Francesco, Fardella, Stefania, Iacobucci, Roberta, Lembo, Giuseppe, Perrotta, Marialuisa, Vinciguerra, Iolanda   +13 more
core   +1 more source